Is NCT03896568 recruiting in Houston, TX?

Yes, NCT03896568 is currently recruiting participants at its Houston, TX location. This idh1 wt allele clinical trial is actively enrolling qualified participants.

How do I join the idh1 wt allele clinical trial in Houston?

To join this clinical trial in Houston, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Houston clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

IDH1 wt Allele Clinical Trial in Houston, TX

About This IDH1 wt Allele Study in Houston

This phase I trial studies best dose and side effects of oncolytic adenovirus DNX-2401 in treating patients with high-grade glioma that has come back (recurrent). Oncolytic adenovirus DNX-2401 is made from the common cold virus that has been changed in the laboratory to make it less likely to cause an infection (such as a cold). The virus is also changed to target brain cancer cells and attack them.

Sponsor: M.D. Anderson Cancer Center

Who Can Participate

Inclusion Criteria

Subjects must meet the following inclusion criteria to be eligible and enroll:

Subjects must be willing and able to provide informed consent, undergo and comply with all study assessments, and adhere to the protocol schedule.

Patients with recurrent malignant GBM or gliosarcoma will be eligible. Patients with recurrent anaplastic astrocytoma with wild-type IDH-1 gene will also be eligible if there is a significant enhancing mass on MRI (≥1.0 cm in diameter with upper limit of 5 cm maximal diameter) because their prognosis/behavior is similar to GBM. Subjects with an initial diagnosis of an IDH-mutant grade 2 or 3 astrocytoma are also eligible at recurrence if a biopsy at recurrence is determined to be IDH-mutant grade 4 astrocytoma, and there is a significant enhancing mass on MRI (≥1.0 cm in diameter with upper limit of 5 cm maximal diameter). A pathology report constitutes adequate documentation of histology for study inclusion.

Patients must show unequivocal evidence for tumor recurrence or progression by MRI scan after failing prior surgical resection, biopsy, chemotherapy or radiation. A baseline MRI must be performed within 24 days prior to registration. Biopsy is encouraged at the time of recurrence if it is unclear that there is recurrent tumor. However, biopsy is not required if the practicing physician thinks that there is adequate radiographic and clinical evidence for recurrence.

Male or female patients ≥ 18 years of age.

Patients must be able to undergo endovascular treatment based on Doppler studies showing ICA that is less than 50% occluded.

For patients undergoing resection for biological endpoints, tumors must be surgically resectable at the time of baseline evaluation and craniotomy for tumor resection is indicated as part of their standard medical care.

Tumors must be ≥1.0 cm in diameter with upper limit of 5 cm maximal diameter.

Patients must have a Karnofsky performance score ≥ 70.

Patients must have a life expectancy of at least 16 weeks.

Patients must have adequate bone marrow function (absolute granulocyte count \> 1,500 and platelet count of \> 75,000), adequate liver function (SGPT and SGOT and bilirubin \< 2 times institutional normal ranges), and adequate renal function (creatinine \< 2.0 times institutional normal) prior to starting therapy.

Prothrombin time/international normalized ratio (PT/INR) or partial thromboplastin time (PTT) ≤ 1.5x ULN.

Subjects who have received the following chemotherapies must have completed them within the following time periods prior to Baseline/Day 0 of hMSC-DNX2401 delivery with recovery from any drug-related toxic effects to Grade 1, or less, severity:

Four weeks from cytotoxic agents (3 weeks from procarbazine or Temozolomide, 2 weeks from vincristine)

6 weeks from nitrosoureas (CCNU, BCNU)

Four weeks from any targeted investigational agent

One week from non-cytotoxic agents

This study was designed to include women and minorities, but was not designed to measure differences of intervention effects. Males and females will be recruited with no preference to gender.

Exclusion Criteria

to this study will be based on race. Minorities will actively be recruited to participate. The malignant glioma patient population treated at MDACC over the past year is as follows:

American Indian or Alaskan Native - 0

Asian or Pacific Islander - \<2%

Black, not of Hispanic Origin - 3%

Hispanic - 6%

White, not of Hispanic Origin - 88%

Other or Unknown - 2%

Total - 100%

Patients must be 8 weeks from radiotherapy to minimize the potential for MRI changes related to radiation necrosis that might be misdiagnosed as progression of disease, or 4 weeks if a new lesion, relative to the pre-radiation MRI, develops that is outside the primary radiation field (beyond 80% isodose line). However, if a biopsy is undertaken prior to these times and this biopsy documents histological evidence for recurrent disease, then patients will be eligible regardless of the time after radiation.

Patients must be willing to forego other cytotoxic and non-cytotoxic drug or radiation therapy against the tumor while enrolled in the study.

Women of childbearing potential must have a negative urine or serum pregnancy test at screening.

Subjects and their partners must be willing to use effective birth control during the study and for up to 6 months following administration of hMSC-DNX2401. Birth control that is acceptable to use in this study:

Using twice the normal protection of birth control (i.e., double-barrier) by using a condom AND spermicidal jelly or foam, or a diaphragm AND spermicidal jelly or foam. A spermicidal jelly or foam must be used in addition to a barrier method (e.g., condom or diaphragm)

Birth control pills ("The Pill")

Depot or injectable birth control

IUD (Intrauterine Device)

Birth Control Patch (e.g., Othro Evra®)

Surgical sterilization (i.e., tubal ligation or hysterectomy for women or vasectomy for men) Exclusion Criteria:

Histology other than GBM, gliosarcoma, IDH wild-type astrocytoma grade III or IDH-mutant astrocytoma grade 4.

Tumor foci detected below the tentorium or beyond the cranial vault.

Tumor within the posterior fossa.

Tumor with leptomeningeal spread.

Difficulty in obtaining vascular access for percutaneous procedure.

Ipsilateral carotid stenosis (\>50%, by Doppler studies).

Thrombophilias or primary hematological diseases.

Transfusions or medications (G-CSF) to treat pancytopenia or other hematological conditions \< 28 days prior to Baseline/Day 0/hMSC-DNX2401 administration.

Biologic/immunotherapy within 2 weeks of baseline.

Clinical or laboratory evidence of inflammatory and/or autoimmune disorders.

Any contraindication for undergoing MRI such as: individuals with pacemakers, epicardial pacer wires, infusion pumps, surgical and/or aneurysm clips, shrapnel, metal prosthesis, implants with potential magnetic properties, metallic bodies in the eyes, etc. In addition, subjects must present with tumor that is evaluable by MRI.

Pregnant or nursing females.

Evidence of active uncontrolled infection or unstable or severe intercurrent medical conditions. All subjects must be afebrile (i.e., \<38.0° Celsius \[C\]).

Any medical condition that precludes surgery or endovascular treatment

Alcoholism (dependency), alcohol or substance abuse within twelve (12) months prior to screening that has caused health consequences.

Immunocompromised subjects or those with autoimmune conditions, active hepatitis (Liver function tests \> 2x normal) or human immunodeficiency virus (HIV) seropositivity.

Evidence of bleeding diathesis or use of anticoagulant medication or any medication that may increase the risk of bleeding that cannot be stopped prior to surgery. If the medication can be discontinued prior to DNX-2401 injection then the subject may be eligible following consultation with the Study Chair. Low weight heparin and Lovenox (enoxaparin) administered on a temporary limited basis for post procedure DVT prophylaxis is permitted.

History or current diagnosis of any medical or psychological condition that in the Investigator's opinion might interfere with the subject's ability to participate or inability to obtain informed consent because of psychiatric or complicating medical problems.

Encephalitis, multiple sclerosis or other central nervous system (CNS) infection or primary CNS disease that would interfere with subject evaluation.

Subjects with known Li-Fraumini Syndrome or with a known germ line deficit in the retinoblastoma gene or its related pathways.

Subjects with significant systemic or major illnesses including but not limited to: congestive heart failure, ischemic heart disease, cerebrovascular disease (history of strokes or TIAs in large vessel or small vessel distribution), kidney disease or renal failure, active liver disease, organ transplantation, or significant psychiatric disorder.

Enrollment in a concomitant therapeutic clinical study.

Any condition that prevents compliance with the protocol or adherence to therapy.

For patients enrolled in the biological endpoint phase of the study, patients will be excluded if in the assessment of the surgeon, after resecting the tumor, there is high likelihood of injecting BM-hMSC-DNX2401 into the ventricles.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT03896568) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

IDH1 wt Allele Treatment Options in Houston, TX

If you're searching for idh1 wt allele treatment options in Houston, TX, this clinical trial (NCT03896568) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced idh1 wt allele specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all idh1 wt allele clinical trials near you to find additional studies recruiting in your area.

IDH1 wt Allele Clinical Trial in Houston, TX

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