NCT07718347 · Lynch Regenerative Medicine
Post-market Cosmetic Evaluation of Ariessence™ Pure PDGF+ Following Ablative Laser
What this study is about
ariessence is intended to be used as a viscous, leave-on solution designed for topical application to the face. It is intended to be used following non-medical cosmetic procedures, performed by licensed healthcare professionals to enhance comfort and maintain skin hydration.
View original scientific description
ariessence is intended to be used as a viscous, leave-on solution designed for topical application to the face. It is intended to be used following non-medical cosmetic procedures, performed by licensed healthcare professionals to enhance comfort and maintain skin hydration. This study is designed to be a multi-center, post-market cosmetic evaluation of ariessence applied to the full face after an ablative laser procedure to evaluate improvements in procedure tolerability and improvements in the appearance of the skin, compared to an emollient control.
Interventions
OTHER
ariessence pure PDGF+™ is a sterile aqueous formulation containing Hyaluronic Acid and pure platelet-derived growth factor (PDGF).
To compare time to appearance-based recovery and subject satisfaction between ariessence and standard of care groups using standardized photographs and investigator/subject ratings for tolerability and satisfaction
Primary outcome measures
Clinical Measures
Time frame: Baseline (Day 0) through Day 84 (End of Study).
Glogau Scale
Patient-Reported Outcomes
Time frame: Baseline through day 84
FACE-Q, SKIN-Q, FACE-Q Psychological Function, treatment Discomfort/Pain Evaluation Subject Satisfaction Scale
Photography
Time frame: Baseline through Day 84
VISIA-CR (standardized frontal ±45°), FitSkin (regional close-ups), and point-and-shoot baseline and follow-ups
Investigator Objective Tolerability Assessment
Time frame: Baseline through Day 84
Tolerability of product
Erythema grading (0-4 scale)
Time frame: Baseline through Day 84 (End of Study)
Degree of erthema
Clinician's Global Aesthetic Improvement Scale (CGAIS).
Time frame: Baseline through Day 84 (End of STudy)
Measure of Aestetic Imporvement
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- -:Adults 40-65 70 years
- Glogau III-IV
- Fitzpatrick II-IV.
- Suitable for ablative laser
- non-smoker ≥ 3 years
- Willing to comply with post-procedure regimen
- patient reported outcome documentation, and photo documentation.
Exclusion criteria
- Fitzpatrick I or \> IV,
- recent facial procedures (\< 6 months)
- active skin disease
- pregnancy/lactation
- implanted devices
- history of keloids.
Where
- Sacramento, California
- Nashville, Tennessee
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 21, 2026 · Source of record for eligibility and locations