Is NCT07663422 recruiting in Philadelphia, PA?

Yes, NCT07663422 is currently recruiting participants at its Philadelphia, PA location. This immune-mediated hepatitis clinical trial is actively enrolling qualified participants.

How do I join the immune-mediated hepatitis clinical trial in Philadelphia?

To join this clinical trial in Philadelphia, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Philadelphia clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Immune-mediated Hepatitis Clinical Trial in Philadelphia, PA

About This Immune-mediated Hepatitis Study in Philadelphia

This phase II study evaluates whether early treatment with mycophenolate mofetil (MMF) plus prednisone improves liver inflammation caused by immune checkpoint inhibitors. The study includes patients who develop moderate to severe immune-related hepatitis after receiving PD-(L)1 or CTLA-4-based cancer therapy. The main goal is to determine how many patients experience improvement in liver function within 30 days while successfully tapering steroids. Safety and treatment-related side effects will also be monitored.

Sponsor: Fox Chase Cancer Center

Who Can Participate

Inclusion Criteria

Patients must be ≥ 18 years at the time of irAE diagnosis and must have been diagnosed with a solid tumor or hematologic malignancy being treated with non-curative intent.

Patients must be diagnosed or presumed to have by a treating Medical Oncology or Hematology-Oncology clinician with immune-related hepatitis, G2-G3 (as defined in section 11.0), with plan for at least temporary interruption of IO therapy and initiation of corticosteroid treatment.

Patients must have been previously treated for any malignancy with at least one dose of an IO agent targeting the Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PDL-1) or CTLA-4 axis. IO use may have occurred at any time prior to diagnosis of irAE.

Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin must have been measured within screening window outlined in Section 8.0 (Study Calendar).

Patient must be able to take study medications by mouth.

Baseline hemoglobin (HgB) at time of enrollment ≥8.0 g/dL, absolute neutrophil count (ANC) ≥ 1500/mm3, and platelet count ≥ 100,000/mm3 without red blood cell or platelet transfusion in the two weeks preceding measurement of lab values. Lab values are to be assessed within screening window outlined in Section 8.0 (Study Calendar).

Baseline estimated Glomerular Filtration Rate (eGFR) \< 30 mL/min/1.73m2

Patients must be able to understand and willing to sign a written informed consent and HIPAA consent document.

Exclusion Criteria

Patients previously treated for irAE hepatitis.

Patients diagnosed or presumed to have G4 immune-related hepatitis.

Patients receiving renal replacement therapy with hemodialysis or peritoneal dialysis at time of enrollment.

Patients with a documented history of Child-Turcotte-Pugh class B and C liver dysfunction.

Patients with significant liver dysfunction at time of presentation, as defined by an otherwise unexplained change in mental status or International Normalized Ratio (INR) ≥ 1.5 attributed to synthetic liver dysfunction.

Patients with active hepatitis B (HBV), hepatitis C (HCV), or tuberculosis. Confirmatory testing for these infections may be performed if no recent result is available in the patient's records and, in the opinion of the treating physician, such testing is clinically warranted. Past HBV is exclusionary. Patients with treated HCV infection and documented eradication are eligible to enroll.

Patients with uncontrolled human immunodeficiency virus (HIV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus (HSV), or Varicella-zoster virus (VZV). Confirmatory testing for these infections is not required.

Patients with a history of gastrointestinal bleeding, ulceration, or perforations within one year of trial enrollment. Use of proton-pump inhibitor therapy is allowed.

Patients with any history of solid organ or allogeneic stem cell transplantation.

Patients with type I diabetes mellitus (DM).

Patients with type II DM with most recent glycated hemoglobin measurement greater than or equal to 9.0%.

Patients with a documented history of phosphoribosyl-transferase deficiency.

History of allergic reactions to MMF, prednisone, methylprednisolone, or dexamethasone.

Patients with decompensated congestive heart failure at time of enrollment, at the discretion of treating clinician, regardless of ejection fraction.

Patients with history of suicidal ideation or past suicide attempt.

Uncontrolled or intercurrent severe medical illness at the time of enrollment, as defined below:

Patients being treated with vasopressors

Patient requiring mechanical ventilation or extracorporeal membrane oxygenation

Patients being treated with parenteral antibiotic, antifungal, or antiviral medications

Patients with chronic autoimmune diseases requiring long-term immunosuppressive treatment at the time of enrollment, or for whom the mechanism of index inflammatory changes is too uncertain to initiate irAE-directed treatment at the discretion of treating provider.

Patients with congenital (e.g. combine variable immunodeficiency) or acquired (e.g. chronic leukemia) immunodeficiency requiring long-term prophylactic antimicrobial treatment at time of enrollment (e.g. intravenous immunoglobulin (IVIg), prophylactic antiviral treatment, etc.)

Women of child-bearing potential (WOCBP) who are pregnant or breast-feeding.

Patients unable to commit to use of reliable contraception throughout the study period.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Philadelphia?

Yes, this clinical trial (NCT07663422) has an active research site in Philadelphia, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Immune-mediated Hepatitis Treatment Options in Philadelphia, PA

If you're searching for immune-mediated hepatitis treatment options in Philadelphia, PA, this clinical trial (NCT07663422) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Philadelphia research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced immune-mediated hepatitis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all immune-mediated hepatitis clinical trials near you to find additional studies recruiting in your area.

Immune-mediated Hepatitis Clinical Trial in Philadelphia, PA

Expert Care in Philadelphia

IRB Approved

No-Cost Care

Apply for This Philadelphia Location

Why Participate?

Simple Process