Is NCT07095127 recruiting in Greenville, NC?

Yes, NCT07095127 is currently recruiting participants at its Greenville, NC location. This immune thrombocytopenia (itp) clinical trial is actively enrolling qualified participants.

How do I join the immune thrombocytopenia (itp) clinical trial in Greenville?

To join this clinical trial in Greenville, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Greenville clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Immune Thrombocytopenia (ITP) Clinical Trial in Greenville, NC

About This Immune Thrombocytopenia (ITP) Study in Greenville

The purpose of the study is to evaluate the safety of NVG-2089 and to evaluate how well patients respond to this investigational treatment. NVG-2089 is a new drug that is being developed for treating patients with ITP. NVG-2089 is designed to mimic the effects of a protein called IVIg. NVG-2089 is designed to help the immune system by attaching (binding) to certain receptors in the body and activating them, which helps reduce inflammation and supports how the immune system works.

Sponsor: Nuvig Therapeutics, Inc.

Who Can Participate

Inclusion Criteria

Males and female participants, age 18 to 80 years at time of screening.

Diagnosis of persistent (\>3 months and ≤12 months), or chronic (\>12 months) primary ITP. If the participant has received prior treatment for ITP, they must have a history of response to at least one previous therapy (defined as increase in platelet count to ≥ 50,000 cells/mm3 with an increase of ≥ 20,000 cells/mm3 relative to platelet count prior to treatment).

Asymptomatic or with minor mucocutaneous bleeding AND platelet count of ≤50,000 cells/mm3, measured on 2 occasions at least 5 days apart during the screening period.

(For US only) If at least one screening platelet count \>30,000 cells/ mm3 and \<50,000 cells/mm3, the participant must be on at least 1 other treatment for ITP with insufficient response as evidenced by platelet count \<50,000 cells/ mm3.

If participant has received prior IVIg therapy participant must have shown a sufficient platelet response (doubling from baseline platelet count within 7 days of IVIg infusion) and must not have lost response to IVIg therapy while on treatment.

Female participants of childbearing potential must have a negative serum pregnancy test at Screening and a negative urine pregnancy test on Day 1.

Female participants who are sexually active with a male partner of reproductive potential must use double contraception (including a barrier contraceptive and another method) from at least 28 days prior to Screening and for 90 days after last dose of study drug; female participants must also refrain from oocyte donation for the purpose of reproduction during this period. Exceptions are made for surgically sterile participants, or post-menopausal females (defined as 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum follicle -stimulating hormone levels \>40 mIU/mL or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy). Abstinence is acceptable if this is the usual lifestyle and preferred contraception for the participant.

Male participants with female partners who are of reproductive potential must agree to the use of highly effective, barrier contraception for the duration of the study, and for 90 days after the last dose of study drug.

Participant is capable or has a legally authorized representative(s) (LAR\[s\]) capable of providing a signed informed consent which includes compliance with the requirements and restrictions listed in the ICF.

Exclusion Criteria

Secondary forms of ITP (e.g., ITP secondary to infection, autoimmune diseases, lymphoproliferative diseases and medications).

History of splenectomy.

History of malignancy, unless the participant received treatment with curative intent. Participants with fully excised non-melanoma skin cancer or cervical cancer are allowed.

History of solid organ transplant.

Planned or anticipated medical or surgical procedure, including dental procedure, during the timeframe of the study conduct.

Clinically significant active or chronic uncontrolled bacterial, viral, or fungal infection at screening, including active viral infection at screening.

Any medical condition that, in the opinion of the investigator, would interfere with study evaluations or procedures, and/or put the participant at increased risk.

ECG findings of QTcF \> 450 msec (males) or \> 470 msec (females), poorly controlled atrial fibrillation or other clinically significant abnormalities.

Other significant organ dysfunction, including but not limited to, hematologic, renal, or hepatic dysfunction, as evidenced by:

Absolute neutrophil count ≤ 1.5 x 109 /L

Hemoglobin (Hgb) \< 9 g/dL

Aspartate aminotransaminase (AST) and/or alanine aminotransferase (ALT) ≥ 2 x the upper limit of normal (ULN),

Albumin ≤ 3 g/dL

Total bilirubin ≥ 1.5 x ULN

Estimated glomerular filtration rate \< 50 mL/min/1.73m2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) method

Any of the following at screening:

Active Hepatitis B Virus (HBV): Hepatitis surface antigen (HBsAg) positive

Active Hepatitis C Virus (HCV): serology positive for HCV-antibody

Human Immunodeficiency Virus (HIV) positive serology

Transfusion of blood, blood products (including immune globulin), or plasmapheresis within 4 weeks prior to screening.

Change in current ITP therapy (e.g., prednisone, methylprednisone, mycophenolate, dapsone, danazol, azathioprine, or TPO receptor agonist) or dose within 4 weeks prior to screening.

Receipt of dexamethasone within 4 weeks prior to screening.

Receipt of rituximab or an anti-CD20 agent within 6 months prior to screening.

Receipt of an neonatal Fc receptor (FcRn) inhibitor within 12 weeks prior to screening.

Receipt of IVIg within 4 weeks prior to screening.

Receipt of another investigational drug within 4-weeks or 5 half-lives (whichever is longer) prior to screening.

Concurrent treatment with other monoclonal antibody and/or Fc therapies.

Current or past history (within 12 months of screening) of alcohol, drug, or medication abuse. Positive urine drug screen at screening visit.

Pregnant or lactating women and those intending to become pregnant during the study or are unwilling to apply an effective birth control method (such as implants, injectables, combined oral contraceptives, intrauterine devices \[IUDs\], sexual abstinence, or vasectomized partner) up to 90 days after last study drug administration.

Poor venous access.

A known allergy to study drug and/or any of its components.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Greenville?

Yes, this clinical trial (NCT07095127) has an active research site in Greenville, NC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Immune Thrombocytopenia (ITP) Treatment Options in Greenville, NC

If you're searching for immune thrombocytopenia (itp) treatment options in Greenville, NC, this clinical trial (NCT07095127) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Greenville research site is actively enrolling participants for this clinical trial. You'll receive care from experienced immune thrombocytopenia (itp) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all immune thrombocytopenia (itp) clinical trials near you to find additional studies recruiting in your area.

Immune Thrombocytopenia (ITP) Clinical Trial in Greenville, NC

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