Palo Alto, CANCT04571203Now EnrollingIRB Ready

Immune Tolerance Clinical Trial in Palo Alto, CA

Access cutting-edge immune tolerance treatment through this clinical trial at a research site in Palo Alto. Study-provided care at no cost to qualified participants.

Sponsored by Stanford University

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Expert Care in Palo Alto

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related immune tolerance treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Palo Alto

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Palo Alto site if eligible
  4. 4Begin participation

About This Immune Tolerance Study in Palo Alto

This is a single arm phase 1 non randomized dose finding study for safety, feasibility and efficacy of deceased donor vertebral body (VB) marrow cell infusion and kidney transplantation.

Sponsor: Stanford University

Who Can Participate

Inclusion Criteria

RECIPIENT INCLUSION CRITERIA:
Patient is ≥ 18 years old, and \<65 years of age.
Has End Stage Renal Disease (ESRD) and is a de novo kidney transplant candidate part Stanford standard of care.
Listed with the Organ Procurement and Transplantation Network (OPTN) for deceased donor transplantation.
A serotypic (Human Leucocyte Antigen) HLA match with the donor of a least 1 locus in A, B or DR.
Males and females of reproductive potential who agree to practice a reliable form of contraception for at least 1 year post transplant.
Females have a negative serum pregnancy test.
Ability to understand and the willingness to sign a written informed consent document. Patients must have signed informed consent to participate in the trial.
No known contraindication to administration of rabbit ATG or low dose irradiation. DONOR INCLUSION CRITERIA:
Brain dead donor aged ≥ 16 and ≤ 55
Organ Procurement Organization (OPO) consent for vertebral body procurement
Organ Procurement Organization consent for research
Projected cold ischemia time \<24 hours.

Exclusion Criteria

RECIPIENT EXCLUSION CRITERIA:
Known allergy to rabbit protein.
History of malignancy with the exception of non melanoma skin malignancy.
Pregnant woman or nursing mother.
Body weight \>90kg or BMI \>35.
Evidence of HIV 1/2 antibody (Ab), HTLV 1 and HTLV 2 Ab (Human T-Lymphotropic Virus), Hepatitis B sAg (surface antigen), Hepatitis C Ab, or positive syphilis screen.
EBV (Epstein Bar Virus)Ab positive donor to EBV Ab negative recipient.
Active bacterial, viral or fungal infection defined as currently taking medication for the infection.
Leukopenia (white blood cell count \< 3000/mm3) or thrombocytopenia (with a platelet count \< 100,000/mm3).
Psychiatric disorder(s) or psychosocial circumstance(s) which in the opinion of the Stanford Transplant team caring for this potential patient would place the patient at an unacceptable risk.
Concern for alcohol or other substance abuse.
Kidney disease at high risk for post transplant recurrence: aHUS (atypical hemolytic- uremic syndrome) and C3 glomerulopathy
Panel reactive antibody (PRA) \>80%.
Positive donor specific antibody (DSA).
Prior or combined organ transplant.
Patients with \>5 pack year smoking history, smoking within 10 years of enrollment, or first degree relative with lung cancer. DONOR EXCLUSION CRITERIA:
History of malignancy with the exception of non melanoma skin malignancy.
History of autoimmune disease.
Known medical diagnosis of Zika virus infection within the prior 6 months, including post mortem screening.
Serological evidence of HIV, Hepatitis B (surface antigen positive), or Hepatitis C infection.
Evidence of systemic infection.
Kidney Donor Profile Index (KDPI) \> 70%.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Palo Alto?

Yes, this clinical trial (NCT04571203) has an active research site in Palo Alto, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Immune Tolerance Treatment Options in Palo Alto, CA

If you're searching for immune tolerance treatment options in Palo Alto, CA, this clinical trial (NCT04571203) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Palo Alto research site is actively enrolling participants for this clinical trial. You'll receive care from experienced immune tolerance specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all immune tolerance clinical trials near you to find additional studies recruiting in your area.

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