Columbus, OHNCT06118567Now EnrollingIRB Ready

Intermittent Explosive Disorder Clinical Trial in Columbus, OH

Access cutting-edge intermittent explosive disorder treatment through this phase 2 clinical trial at a research site in Columbus. Study-provided care at no cost to qualified participants.

Sponsored by Ohio State University

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Expert Care in Columbus

Access intermittent explosive disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related intermittent explosive disorder treatment provided free

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Check if you qualify for this intermittent explosive disorder clinical trial in Columbus, OH

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Why Participate?

  • No-Cost Study Care

  • Local to Columbus

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Columbus site if eligible
  4. 4Begin participation

About This Intermittent Explosive Disorder Study in Columbus

The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive tendencies. The main question aims to answer are: Does Nitrous Oxide normalize brain circuit function in impulsively aggressive individuals 24 hours after inhalation. Participants will undergo a 60 minute inhalation session with 50% Nitrous Oxide (or room air at another session) and then undergo an fMRI scan 24 hours later. Researchers will compare healthy controls and impulsively aggressive individuals to see if Nitrous Oxide can normalize the function of cortico-limbic circuits in the latter group.

Sponsor: Ohio State University

Who Can Participate

Inclusion Criteria

All participants:
Between 21 and 55 years of age.
Physically healthy (no clinically significant medical condition as confirmed by medical history/physical exam).
Able to give informed consent. Aggressive (IED) Study Participants (n = 25 Completed; 75 Enrolled).
Current DSM-5 Criteria for IED
LHA Aggression scores \> 12
Negative for a history of psychosis, bipolar disorder, developmental disorder, intellectual disability or a current substance use disorder. Healthy, Non-Aggressive, Controls (n = 25 Completed, 75 Enrolled).
Do not meet current/lifetime DSM-5 Criteria for any psychiatric disorder
LHA aggression scores \< 12

Exclusion Criteria

PCL Screening Version Score \> 13; i.e., subject is likely to be psychopathic.32
Current DSM-5 Major Depressive Episode.
Life history of bipolar disorder/schizophrenia/organic mental syndrome.
Intellectual disability \[i.e., IQ \< 70\].
History of N2O abuse/dependence.
Clinically significant medical condition.
Current alcohol/drug use disorder of moderate or severe severity (i.e., subject is not in full remission from moderate to severe alcohol/drug use).
Two weeks free of antipsychotic medication. (Note: Because a large number of individuals with aggressive tendencies in the community are already taking SSRIs, SNRIs, or mood stabilizers, these individuals will not be excluded if they continue to report impulsive aggressive behaviors at time of study.)
Unwilling/unable to sign informed consent document.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Columbus?

Yes, this clinical trial (NCT06118567) has an active research site in Columbus, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Intermittent Explosive Disorder Treatment Options in Columbus, OH

If you're searching for intermittent explosive disorder treatment options in Columbus, OH, this clinical trial (NCT06118567) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Columbus research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced intermittent explosive disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all intermittent explosive disorder clinical trials near you to find additional studies recruiting in your area.

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