Is NCT07227246 recruiting in Downey, CA?

Yes, NCT07227246 is currently recruiting participants at its Downey, CA location. This intracerebral hemorrhage clinical trial is actively enrolling qualified participants.

How do I join the intracerebral hemorrhage clinical trial in Downey?

To join this clinical trial in Downey, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Downey clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Intracerebral Hemorrhage Clinical Trial in Downey, CA

About This Intracerebral Hemorrhage Study in Downey

The objective of the rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial is to establish the first treatment for acute spontaneous intracerebral hemorrhage (ICH) within a time window and subgroup of patients that is most likely to benefit. The central hypothesis is that rFVIIa, administered within 120 minutes from stroke onset with an identified subgroup of patients most likely to benefit, will improve outcomes at 90 days as measured by the Modified Rankin Score (mRS) and decrease ongoing bleeding as compared to standard therapy. FASTEST Part 2 is an extension of the FASTEST Trial where the subgroups include those treated within 2 hours with a positive spot sign on a baseline CT angiogram or patients treated within 90 minutes of stroke onset, with or without a positive spot sign.

Sponsor: Joseph Broderick, MD

Who Can Participate

Inclusion Criteria

Patients aged 18-80 years, inclusive

Patients with spontaneous ICH

Able to treat with study medication (rFVIIa/placebo) within 120 minutes of stroke onset or last known well with a positive spot sign on pretreatment CT angiography or treatment within 90 minutes with or without spot sign.

Efforts to obtain informed consent per EFIC guidelines (U.S.) or adherence to country-specific emergency research informed consent regulations (Canada, Germany, Spain, Finland, U.K., Japan, Australia)

Exclusion Criteria

Score of 3 to 7 on the Glasgow Coma Scale

Secondary ICH related to known causes (e.g., trauma, aneurysm, arteriovenous malformation (AVM), oral anticoagulant use (vitamin K antagonists or novel oral anticoagulants) within the past 7 days, coagulopathy, etc.)

ICH volume \< 2 cc or ≥ 60 cc

Blood filling 2/3 or more of one lateral ventricle of the brain, OR, blood filling at least 1/3 of both lateral ventricles.

Pre-existing disability (mRS \> 2)

Symptomatic thrombotic or vaso-occlusive disease in past 90 days (e.g., cerebral infarction, myocardial infarction, pulmonary embolus, deep vein thrombosis, or unstable angina)

Clinical or EKG evidence of ST elevation consistent with acute myocardial ischemia

Brainstem location of hemorrhage (patients with cerebellar hemorrhage may be enrolled)

Refusal to participate in study by patient, legal representative, or family member

Known or suspected thrombocytopenia (unless current platelet count documented above 50,000/μL)

Unfractionated heparin use with abnormal PTT

Pro-coagulant drugs within 24 hours prior to patient enrollment into the FASTEST trial (example, tranexamic acid or aminocaproic acid)

Low-molecular weight heparin use within the previous 24 hours

Recent (within 90 days) carotid endarterectomy or coronary or cerebrovascular angioplasty or stenting

Advanced or terminal illness or any other condition the investigator feels would pose a significant hazard to the patient if rFVIIa were administered

Recent (within 30 days) participation in any investigational drug or device trial or earlier participation in any investigational drug or device trial for which the duration of effect is expected to persist until to the time of FASTEST enrollment

Planned withdrawal of care or comfort care measures

Patient known or suspected of not being able to comply with trial protocol (e.g., due to alcoholism, drug dependency, or psychological disorder)

Known or suspected allergy to trial medication(s), excipients, or related products

Contraindications to study medication

Previous participation in this trial (previously randomized)

Females of childbearing potential who are known to be pregnant or within 12 weeks post-partum and/or lactating at time of enrollment -

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Downey?

Yes, this clinical trial (NCT07227246) has an active research site in Downey, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Intracerebral Hemorrhage Treatment Options in Downey, CA

If you're searching for intracerebral hemorrhage treatment options in Downey, CA, this clinical trial (NCT07227246) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Downey research site is actively enrolling participants for this clinical trial. You'll receive care from experienced intracerebral hemorrhage specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all intracerebral hemorrhage clinical trials near you to find additional studies recruiting in your area.

Intracerebral Hemorrhage Clinical Trial in Downey, CA

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