NCT04281017 · University of Florida
Effect of Position and Anesthetic Choice in Intraocular Pressure in Robotic GYN (Gynecologic) Oncology Patients
What this study is about
Steep Trendelenburg positioning and insufflation of the abdominal cavity have shown to increase intra ocular pressure. Different anesthetic techniques can alter intra ocular pressure and a small pilot study showed decrease in Intraocular Pressure (IOP) in robotic case in steep Trendelenburg with IV anesthetics (TIVA).
View original scientific description
Steep Trendelenburg positioning and insufflation of the abdominal cavity have shown to increase intra ocular pressure. Different anesthetic techniques can alter intra ocular pressure and a small pilot study showed decrease in Intraocular Pressure (IOP) in robotic case in steep Trendelenburg with IV anesthetics (TIVA). We want to quantify the degree of change in Intraocular Pressure (IOP) in female patients undergoing robotic procedures for cancer.
Interventions
DRUG
TIVA
Induction with 1% propofol (2-3 mg/kg), fentanyl (1-3 mg/kg), and Rocuronium 1-1.5 mg/kg. Before the injection of propofol, 5 mL 1% lidocaine (50 mg)
DRUG
Balanced anesthesia
Induction with 1% propofol (2-3 mg/kg), fentanyl (1-3 mg/kg), and Rocuronium 1-1.5 mg/kg. Before the injection of propofol, 5 mL 1% lidocaine (50 mg
Primary outcome measures
Quantify the degree of change in intra ocular pressure in female patients undergoing robotic procedures
Time frame: Day of Surgery
quantify the degree of change in IOP in female patients undergoing robotic procedures for cancer
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Females ≥ eighteen years of age
- Written informed consent obtained from the subject and the subject agrees to comply with all the study-related procedures
- Subjects must be planning to receive robotic surgery for gynecological cancer or high suspicion of cancer (these subject will be withdrawn if it his proven they don't have cancer)
- Subjects must be cleared for surgery by the pre-anesthesia clinic
- All robotic GYN cancer patients 18 years of age and older with any preexisting medical conditions that are deemed ready for surgery by the pre anesthesia clinic
Exclusion criteria
- Known increased intraocular pressure, prior eye surgery within a month, eye conditions where the ophthalmologist would not allow an intra ocular pressure measurement
- Subjects with a previous treatment of diagnosis of increased intraocular pressure
- Subjects who have undergone eye surgery in the 30 days prior to consent
- Subjects for whom an ophthalmologist has determined cannot undergo intraocular pressure measurement
Where
- Gainesville, Florida
Related conditions & keywords
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Data: ClinicalTrials.gov · synced Jan 16, 2026 · Source of record for eligibility and locations