Toledo, OHNCT06949228Now EnrollingIRB Ready

Ischemic Stroke Clinical Trial in Toledo, OH

Access cutting-edge ischemic stroke treatment through this phase 2/3 clinical trial at a research site in Toledo. Study-provided care at no cost to qualified participants.

Sponsored by ProMedica Health System

Quick Self-Assessment

See if you qualify for this Toledo location

Preparing your pre-screening questions…

Expert Care in Toledo

Access ischemic stroke specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related ischemic stroke treatment provided free

Apply for This Toledo Location

Check if you qualify for this ischemic stroke clinical trial in Toledo, OH

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Toledo

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Toledo site if eligible
  4. 4Begin participation

About This Ischemic Stroke Study in Toledo

The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation of Internal Carotid Artery (ICA), Middle Cerebral Arteries (M1 and M2) who achieve a reperfusion grade of Modified Treatment in Cerebral Ischemia Scale (mTICI) 2b or higher post-mechanical thrombectomy using Food and Drug Administration (FDA) approved devices.

Sponsor: ProMedica Health System

Who Can Participate

Inclusion Criteria

Anterior circulation ischemic stroke symptoms with confirmed occlusion (ICA, M1, or M2) on angiogram and mechanical thrombectomy initiated within 24 hours since last known well
Alberta Stroke Program Early CT Score (ASPECTS) Score ≥6 on baseline Non-contrast Head CT (NCCT)
Post-mechanical thrombectomy with ≤5 device passes and mTICI grade 2b or higher.
Ability to obtain signed informed consent prior to randomization from LAR or Subject

Exclusion Criteria

Premorbid modified Rankin scale (mRS) score \>1
Imaging evidence of hemorrhage or mass effect at baseline
Platelet count \<100,000
Active hemorrhagic diathesis, or known hereditary or acquired hemorrhagic diathesis, coagulation factor deficiency
Active anticoagulation treatment with novel oral anticoagulant (NOACs) taken within the last 48 hours, or INR \>1.7
Patients requiring active treatment with dual antiplatelet agents (e.g. proximal cervical carotid artery stenting)
Pregnant or lactating
Previous known allergy to TNK
Major surgery in past 30 days
Patient is on or requires dialysis
History of intracranial hemorrhage or serious head trauma at any time
Any condition in the opinion of the enrolling physician that would preclude the patient from participating
Pre-existing medical, neurological, or psychiatric disease that would confound the neurological or functional evaluation
Severe, uncontrolled hypertension (systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg) that is refractory to treatment
History of acute ischemic stroke in the last 60 days and/or has received previous treatment with a thrombolytic within the last 90 days
Presumed septic embolus; suspicion of bacterial endocarditis
Suspicion of aortic dissection
Intracranial neoplasm
Any terminal medical condition with life expectancy less than 6 months
Concurrent enrollment in another trial that could confound the results of this study
Patient is unlikely to return for 90-day follow-up.
Intravenous tissue plasminogen activator (tPA) administered concurrently with Intra-arterial TNK

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Toledo?

Yes, this clinical trial (NCT06949228) has an active research site in Toledo, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Ischemic Stroke Treatment Options in Toledo, OH

If you're searching for ischemic stroke treatment options in Toledo, OH, this clinical trial (NCT06949228) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Toledo research site is actively enrolling participants for this phase 2/3 clinical trial. You'll receive care from experienced ischemic stroke specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all ischemic stroke clinical trials near you to find additional studies recruiting in your area.

More Stroke Trials in Toledo, OH

See all stroke clinical trials recruiting in Toledo — not just this study.

Browse Stroke Trials in Toledo →

Browse More Trials by Condition

Stroke TrialsHeart Attack TrialsInterstitial Cystitis TrialsMyocardial Infarction TrialsAll Conditions →

Ready to Join in Toledo?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Toledo, OH