Is NCT06657794 recruiting in Cleveland, OH?

Yes, NCT06657794 is currently recruiting participants at its Cleveland, OH location. This juxtarenal aortic aneurysm clinical trial is actively enrolling qualified participants.

How do I join the juxtarenal aortic aneurysm clinical trial in Cleveland?

To join this clinical trial in Cleveland, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Cleveland clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Juxtarenal Aortic Aneurysm Clinical Trial in Cleveland, OH

About This Juxtarenal Aortic Aneurysm Study in Cleveland

The primary objective of the clinical investigation "Physician Modified Endovascular Grafts for the Treatment of Elective, Symptomatic or Ruptured Juxtarenal Aortic Aneurysms" is to assess the use of the Physician-Modified Endovascular Grafts to repair juxtarenal aneurysms in high-risk subjects considered to be unsuitable candidates for open surgical repair, have limited or no other options for treatment, and having appropriate anatomy. The primary intent of the study is to assess safety and preliminary effectiveness of the device: * acutely (i.e., treatment success and technical success); * at 30 days (i.e., the rate of major adverse events (MAE)); and * at 6 months, 12 months and annually to 5 years (i.e., the proportion of treatment group subjects that achieve and maintain treatment success).

Sponsor: The Cleveland Clinic

Who Can Participate

Inclusion Criteria

All patients must meet all of the following inclusion criteria to be eligible for enrollment into the study:

Patient is ≥ 18 years of age

Patients who are male or non-pregnant female (females of child bearing potential must have a negative pregnancy test prior to enrollment into the study)

Patient or Legally Authorized Representative has signed an Institutional Review Board (IRB) approved Informed Consent Form

Patient has a juxtarenal abdominal aortic aneurysm that meets at least one of the following:

An aneurysm with a maximum diameter of ≥ 5.5 cm for male (≥ 5.0 cm for female) or 2 times the normal diameter just proximal to the aneurysm using orthogonal (i.e., perpendicular to the centerline) measurements

Aneurysm with a history of growth \> 0.5 cm in 6 months

Saccular aneurysm deemed at significant risk for rupture

Symptomatic aneurysm

Ruptured aneurysm

Patient has patent iliac or femoral arteries, with or without the use of conduit, that will allow endovascular access with the physician modified endovascular graft.

Patient has a suitable non-aneurysmal proximal aortic neck of ≥ 2 mm inferior to the most distal renal artery ostium.

Patient has a suitable non-aneurysmal distal iliac artery length (seal zone) of ≥ 15mm. The resultant repair should preserve patency in at least one hypogastric artery.

Patient has a suitable non-aneurysmal proximal aortic neck diameter between 20 and 32 mm, averaged across the diameters at the Celiac, SMA, at the lowest patent renal artery and at the midpoint of the renal arteries.

Patient has suitable non-aneurysmal distal common iliac diameters between 8 and 20 mm.

Patient has juxtarenal aortic neck angulation ≤ 60°

Target branch vessel diameter ≥ 5 mm.

Patient must be willing to comply with all required follow-up exams.

Exclusion Criteria

Patients that meet ANY of the following are not eligible for enrollment into the study:

Patient has a mycotic aneurysm or has an active systemic or local infection that may increase the risk of endovascular infection

Patient has unstable angina (defined as angina with a progressive increase in symptoms, new onset at rest or nocturnal angina, or onset of prolonged angina)

Patient has a major surgical or interventional procedure, not related to the endovascular repair, planned within +/- 30 days of the AAA repair.

Patient has history of an aortopathic connective tissue disease (e.g. Marfan's or Ehler's-Danlos syndrome).

Patient has a known hypersensitivity or contraindication to anticoagulation or contrast media that is not amenable to pre-treatment.

Patient has known allergy or intolerance to stainless steel, nitinol or gold (gold-coated tungsten).

Patient has a body habitus that would inhibit X-ray visualization of the aorta

Patient has a limited life expectancy of less than 1 year

Patient is currently participating in another investigational device or drug clinical trial

Patient has other medical, social or psychological conditions that, in the opinion of the investigator, preclude them from receiving the pretreatment, required treatment, and post-treatment procedures and evaluations.

Thrombus or excessive calcification within the neck of the aneurysm

Branch vessel stenosis ≥ 80%

Patient treatable on label with FDA approved EVAR or FEVAR device and can wait for device availability.

Subject is willing and eligible to enroll in a manufacturer-sponsored study at the investigational site, or the subject is willing and eligible to participate in a study with a manufacturer-made device at another institution.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Cleveland?

Yes, this clinical trial (NCT06657794) has an active research site in Cleveland, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Juxtarenal Aortic Aneurysm Treatment Options in Cleveland, OH

If you're searching for juxtarenal aortic aneurysm treatment options in Cleveland, OH, this clinical trial (NCT06657794) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Cleveland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced juxtarenal aortic aneurysm specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all juxtarenal aortic aneurysm clinical trials near you to find additional studies recruiting in your area.

Juxtarenal Aortic Aneurysm Clinical Trial in Cleveland, OH

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