NCT07291245 · University of California, San Diego
Kawasaki MATCH Trial
(MATCH)
What this study is about
Evaluating the impact of a machine-learning clinical decision support tool on provider practice when evaluating febrile patients with Kawasaki Disease (KD) and non-KD illnesses.
View original scientific description
Evaluating the impact of a machine-learning clinical decision support tool on provider practice when evaluating febrile patients with Kawasaki Disease (KD) and non-KD illnesses.
Interventions
OTHER
Kawasaki MATCH
Providers access the Kawasaki MATCH decision support tool. Patient information is entered into the tool and a risk score is indicated to the provider. Kawasaki MATCH is a previously validated machine-learning decision support tool for the diagnosis of Kawasaki Disease. This tool utilizes patient age, 18 laboratory features, and 5 clinical features to formulate a risk score.
Primary outcome measures
Time to Kawasaki Disease treatment (KD patients only)
Time frame: 90 days
Time in days from initial ED evaluation to initial IVIG treatment in patients ultimately diagnosed with Kawasaki Disease
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Measured or subjective fever for \>= 3 calendar days
- One measured fever \>= 38.0 C (home or in ED)
- One or more clinical feature of Kawasaki Disease including:
- Conjunctival injection
- Oropharyngeal changes
- Extremity changes (erythema, edema, desquamation)
- Cervical adenopathy (\>=1.5cm)
- Infants \< 6 months of age with \>= 7 days of fever eligible even if none of the above clinical features
- Requires IV/phlebotomy for clinical evaluation
Exclusion criteria
- Congenital or Acquired Immune function
- Genetic disorders
- Current systemic steroid, immunosuppression, or chemotherapy treatment (not including inhaled steroids)
Where
- San Diego, California
Collaborators
Gordon and Marilyn Macklin Foundation, Rady Children's Hospital, San Diego
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Dec 18, 2025 · Source of record for eligibility and locations