Aurora, CONCT06140537Now EnrollingIRB Ready

Kidney Transplant; Complications Clinical Trial in Aurora, CO

Access cutting-edge kidney transplant; complications treatment through this clinical trial at a research site in Aurora. Study-provided care at no cost to qualified participants.

Sponsored by University of Colorado, Denver

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Expert Care in Aurora

Access kidney transplant; complications specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related kidney transplant; complications treatment provided free

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Check if you qualify for this kidney transplant; complications clinical trial in Aurora, CO

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Aurora

    Convenient for CO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Aurora site if eligible
  4. 4Begin participation

About This Kidney Transplant; Complications Study in Aurora

Long-term allograft function in kidney transplant recipients (KTRs) remain suboptimal, and graft failure causes significant morbidity and mortality, with cardiovascular disease being the leading cause of death in KTRs and the most common cause of death with a functioning graft. Sodium-glucose cotransporter 2 (SGLT2) inhibitors safely lower cardiovascular and kidney disease risk in the non-transplant population, yet data in KTRs are lacking. This clinical trial seeks to establish the efficacy and safety of dapagliflozin, a SGLT2 inhibitor, for improving cardiovascular and kidney graft function in adult KTRs with type 2 diabetes and post-transplant diabetes, and to leverage innovate translational methods to define the underlying mechanisms of action.

Sponsor: University of Colorado, Denver

Who Can Participate

Inclusion Criteria

Age 18-80 years
Kidney transplant received 1 year prior to randomization
estimated glomerular filtration rate 30-90 ml/min/1.73m2
Urine albumin to creatinine ratio (ACR) 30-5000 mg/g
Pre-existing type 2 diabetes or post-transplant diabetes mellitus
Blood pressure \<130/80 mm Hg prior to randomization
Able to provide informed consent
Stable immunosuppression for at least 3 months prior to baseline consisting of tacrolimus, mycophenolate mofetil/mycophenolic acid and prednisone
Stable anti-hypertensive regimen for at least 1month prior to baseline
Stable diabetes management for at least 3 months prior to baseline
Stable angiotensin converting enzyme inhibitor/angiotensin receptor blocker use for at least 3 months prior to baseline (if applicable)
Glucagon-like peptide-1 receptor agonist (GLP-1RA) for at least 3 months prior to baseline (if applicable)

Exclusion Criteria

Type 1 diabetes
Anticipated life expectancy \<1 year
Uncontrolled hypertension
Hemoglobin A1c \>9%
Body mass index \>40 kg/m2
New York Heart Association Class 3 or 4 heart failure symptoms, an EF ≤30%, or hospitalization for heart failure in the past 3 months
Pregnancy, plans to become pregnant, or breastfeeding
Current use of sodium glucose cotransporter-2 (SGLT2) inhibitors
Current urinary or urogenital infection
Use of anticoagulants (contraindication to kidney biopsy)
Magnetic resonance imaging (MRI) contraindications
History of lower-limb amputation irrespective of etiology
Known hypersensitivity to dapagliflozin

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Aurora?

Yes, this clinical trial (NCT06140537) has an active research site in Aurora, CO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Kidney Transplant; Complications Treatment Options in Aurora, CO

If you're searching for kidney transplant; complications treatment options in Aurora, CO, this clinical trial (NCT06140537) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Aurora research site is actively enrolling participants for this clinical trial. You'll receive care from experienced kidney transplant; complications specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all kidney transplant; complications clinical trials near you to find additional studies recruiting in your area.

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