NCT07786207 · Smith & Nephew, Inc.
Knee Cartilage Repair Registry
(C-SHORE)
What this study is about
This registry is designed to collect information on how different surgical procedures are used and how well they work in treating knee cartilage damage. Information will be collected from patients undergoing knee surgery for cartilage damage and entered into a large database that reflects routine clinical practice ("real-world" data).
View original scientific description
This registry is designed to collect information on how different surgical procedures are used and how well they work in treating knee cartilage damage. Information will be collected from patients undergoing knee surgery for cartilage damage and entered into a large database that reflects routine clinical practice ("real-world" data). The data collected will be used to support future research and improve understanding of treatment outcomes for knee cartilage repair.
Interventions
DEVICE
Marketed Product - MP01
Marketed Product - MP01 is a medical device used in the treatment of knee-joint surface lesions.
PROCEDURE
Other Surgical Treatments
Any other surgical procedures used in the treatment of knee-joint surface lesions that fall within the Marketed Product - MP01 on label indication.
Primary outcome measures
International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score change from Baseline to 24-months
Time frame: Baseline and 24 months
The IKDC Subjective Knee Evaluation Form assesses the subject's opinion of their knee across 3 domains: symptoms (7 items), sports activity (2 items), and knee function (2 items; note: 'function prior to knee injury' is not included in the overall score). Responses vary for each item. The sum of all items is converted to a scale of 0 to 100, where 100 represents no limitation with activities \& absence of symptoms (i.e., the best outcome) and 0 represents the worst outcome.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Prospective Subjects
- Provides written informed consent.
- Is eighteen (18) years of age or older at time of consent and considered skeletally mature in the opinion of the investigator.
- Scheduled to undergo knee cartilage surgery with the Marketed Product-MP01 OR other knee cartilage repair surgery.
- For subjects having other knee cartilage repair surgery: \- Falls within Marketed Product-MP01 on label indication: Knee chondral or osteochondral lesions (ICRS grade III and above, 1-7cm2) in patients with or without mild-moderate knee osteoarthritis (K/L 0-3).
- Has an electronic device and is willing and able to use the device to complete the 'Electronic Clinical Outcomes Assessment' (eCOA).
- Willing and able to complete all requested questionnaires.
- Able to follow instructions and deemed capable of completing registry protocol requirements. Retrospective/Prospective Subjects
- Provides written informed consent.
- Was eighteen (18) years of age or older at time of surgery and considered skeletally mature at that time in the opinion of the investigator.
- Underwent knee cartilage repair surgery with the Marketed Product-MP01 within the last 2-years.
- Has an electronic device and is willing and able to use the device to complete the eCOA.
- Willing and able to complete all requested questionnaires.
- Able to follow instructions and deemed capable of completing registry protocol requirements.
- Consents to retrospective data being collected from pre-operative visit(s) and surgery through to the point of consent as available in their medical notes.
Exclusion criteria
- History of allergic reaction or intolerance of materials containing calcium carbonate or hyaluronate/coral derivatives.
- Is actively participating in a cartilage repair clinical trial.
- For subjects having other knee cartilage repair surgery: \- Treatment will be on patellar lesion(s).
- Has participated previously in this registry (with the index or contralateral knee).
- Meets the definition of a Vulnerable Subject per ISO 14155 Section 3.56.
Where
- Parker, Colorado
- Washington D.C., District of Columbia
- Indianapolis, Indiana
- Bowling Green, Kentucky
- Oklahoma City, Oklahoma
- DuBois, Pennsylvania
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 8, 2026 · Source of record for eligibility and locations