Cambridge, MANCT07652437Now EnrollingIRB Ready

Knee Osteoarthristis Clinical Trial in Cambridge, MA

Access cutting-edge knee osteoarthristis treatment through this clinical trial at a research site in Cambridge. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts Institute of Technology

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Expert Care in Cambridge

Access knee osteoarthristis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related knee osteoarthristis treatment provided free

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Check if you qualify for this knee osteoarthristis clinical trial in Cambridge, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Cambridge

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Cambridge site if eligible
  4. 4Begin participation

About This Knee Osteoarthristis Study in Cambridge

Knee osteoarthritis (OA) affects an estimated 654 million people over age 40 world-wide. In the United States, approximately 16% of adults over the age of 40 have knee OA. Pain, activity limitations and disability are common symptoms. Exercise is widely recommended as a non-invasive, first line strategy for people with knee OA. Yet, less than 1/3 of adults with knee OA meet recommended levels of physical activity, and rates are even lower among people who are overweight. Furthermore, adherence to evidence-based structured programs is poor once the therapeutic support is removed. End stage disease is treated by total joint replacement. Under-active people with knee OA would benefit from general walking activity, even if joint replacement surgery is expected; however, walking is difficult and motivation is low. Thus, people with knee OA encounter a difficult paradox: exercise could help decrease pain and improve function but doing so can be difficult and may not always be possible. There is a tremendous need to address this situation. This is a small device-feasibility study evaluating the Dephy ExoBoot, a wearable powered exoskeleton, in individuals with knee OA. The study assesses whether the device can reliably deliver positive assistance during walking and is tolerated across walking tasks. Additional measures, including changes in knee loading and walking speed with versus without the device, are also collected.

Sponsor: Massachusetts Institute of Technology

Who Can Participate

Inclusion Criteria

21+ years of age
Doctor-diagnosed tibiofemoral knee osteoarthritis
Self-report knee pain or stiffness on most days of the past month
Self-report of difficulty walking due to at least one knee
Self-report of restricted walking behavior (not engaging in 150 minutes of moderate walking a week) due to at least in part one knee
Able to walk one block without the use of an assistive device (e.g. a cane or walker)
Able to engage in a walking activity program with the wearable intervention for approximately 30 minutes using standing or sitting rests as needed

Exclusion Criteria

Unable to walk at least 10 minutes in the community due to an existing cardiovascular, cardiopulmonary, musculoskeletal, or neurological condition
Planning knee, hip, ankle or back surgery within the next 6-months
Ankle or hip osteoarthritis
Inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis, scleroderma, Lymes Disease, Lupus)
Bilateral total knee replacements
Use of an assistive device (e.g., walker or cane) in home or in the community
Self-reported fall within the past 6-months that resulted in limitations in daily activities
Lower extremity/foot peripheral neuropathy or other sensory disorders
Diagnosed with vestibular or other balance disorder that impact walking
Open wounds or active skin irritation on the leg shank
Open wounds or active ulcers of either feet
Unstable cardiovascular disease
Unstable respiratory disease
History of past or current deep vein thrombosis
Active back pain that limits walking
Use of supplemental oxygen to walk

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Cambridge?

Yes, this clinical trial (NCT07652437) has an active research site in Cambridge, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Knee Osteoarthristis Treatment Options in Cambridge, MA

If you're searching for knee osteoarthristis treatment options in Cambridge, MA, this clinical trial (NCT07652437) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Cambridge research site is actively enrolling participants for this clinical trial. You'll receive care from experienced knee osteoarthristis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all knee osteoarthristis clinical trials near you to find additional studies recruiting in your area.

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