NCT06857123 · University of Pittsburgh
Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis
(CaRE)
What this study is about
This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.
View original scientific description
This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age between 45 and 79 yo.
- Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.
- BMI range \< 35 kg/m2.
- Sedentary lifestyle
- Knee joint is the most painful joint in the body.
- Ability to speak and understand English.
- Willingness to comply with all study procedures and be available for the duration of the study.
Exclusion criteria
- Non-OA disease of the knee.
- Advanced knee osteoarthritis
- Knee injection in the past 3 months.
- Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..
- Participate in regular exercise or physical activity .
- Participation in an intervention study for knee OA.
- Currently using a cane, walker or crutches to walk.
- History of cardiovascular disease or hypertension not controlled by medication.
- Two or more unexplained falls in the past year.
- Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.
- Contraindication to MRI.
- Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures.
- Pregnant female.
- Acute or terminal illness.
Where
- Pittsburgh, Pennsylvania
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Feb 9, 2026 · Source of record for eligibility and locations