NCT07491367 · University of California, San Francisco
Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems
(PRP-PEPC)
What this study is about
The investigators would like to study the differences in the quality of Platelet Rich Plasma (PRP) between two different machines in those with knee osteoarthritis. Knee osteoarthritis means your cartilage has been worn down, and it affects your knee joint.
View original scientific description
The investigators would like to study the differences in the quality of Platelet Rich Plasma (PRP) between two different machines in those with knee osteoarthritis. Knee osteoarthritis means your cartilage has been worn down, and it affects your knee joint. Both machines, the APEX Biologix XCELL PRP System and the Emcyte PurePRP Supraphysiologic Concentrating System, are FDA approved, commercially available, and makes PRP. The investigators will check if the platelets in the PRP have different amounts or work differently. The investigators will also assess participants symptoms after the injection and compare the two different preparation systems.
Interventions
BIOLOGICAL
Platelet Rich Plasma
The Platelet Rich Plasma (PRP) participants will receive in this study will be made by Emcyte PurePRP Supraphysiologic Concentrating System or the APEX Biologix XCELL PRP System.
DEVICE
Emcyte PurePRP Supraphysiologic Concentrating System
Platelet Rich Plasma (PRP) will be made by the Emcyte PurePRP Supraphysiologic Concentrating System.
DEVICE
APEX Biologix XCELL PRP System
Platelet Rich Plasma (PRP) will be made by APEX Biologix XCELL PRP System.
Primary outcome measures
Cellular composition and quantity using Horiba Cell counter
Time frame: Day 1
Compare cellular composition and quantifying PRP products between EmCyte PurePRP versus APEX Biologix XCELL PRP manufacturing systems using a Horiba Cell counter.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Kellgren-Lawrence (KL) Grade 1-3 knee osteoarthritis
- Symptoms of knee osteoarthritis for at least 3 months before presentation in one knee
- Will be able to attend and perform physical therapy
Exclusion criteria
- Received injection therapy for knee osteoarthritis in the past 6 months
- Have severe arthritis diagnosed in ≥1 major joint by radiology criteria
- History of septic arthritis
- Underwent knee surgery for osteoarthritis or osteochondral defects within 1 year before randomization (e.g., autograft or allograft surgery)
- Have had high tibial osteotomy, partial knee replacement, patellar resurfacing, total knee replacement, or have existing surgical hardware in the knee
- Received a platelet-rich plasma injection elsewhere in the body within the past 3 months
- Have a platelet disorder or bleeding disorder
- Have a rheumatologic disease, autoimmune disorder, immunocompromised status, or active history of cancer
- Are taking chemotherapy, require regular prednisone, or require regular anti-inflammatory use
- Are pregnant, breastfeeding, or unwilling to practice birth control during the study
- If both knees have osteoarthritis and the other knee has KL score equal to or greater than 2.
- Have uncontrolled illness, physical disability, or other contraindication to aerobic exercise training
Where
- San Francisco, California
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 18, 2026 · Source of record for eligibility and locations