Is NCT07098806 recruiting in San Antonio, TX?

Yes, NCT07098806 is currently recruiting participants at its San Antonio, TX location. This leptomeningeal metastasis clinical trial is actively enrolling qualified participants.

How do I join the leptomeningeal metastasis clinical trial in San Antonio?

To join this clinical trial in San Antonio, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this San Antonio clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Leptomeningeal Metastasis Clinical Trial in San Antonio, TX

About This Leptomeningeal Metastasis Study in San Antonio

This is an open-label, multicenter, Phase 1 study to determine the safety and efficacy of multiple doses at defined intervals of rhenium (186Re) obisbemeda (rhenium-186 nanoliposome, 186RNL) administered via intraventricular catheter for any primary solid tumor cancer with leptomeningeal metastases to identify an MTD/MFD for a given dose, interval duration, and number of doses.

Sponsor: Plus Therapeutics

Who Can Participate

Inclusion Criteria

At least 18 years of age.

Ability to understand the purposes and risks of the study and has signed a written informed consent document approved by the site-specific IRB.

Documented LM from any primary solid tumor cancer per EANO-ESMO Clinical Practice Guidelines (Types I or IIA-C).

Karnofsky performance status of 70 to 100.

Acceptable liver function:

Bilirubin ≤ 1.5 times the upper limit of normal.

AST (SGOT) and ALT (SGPT) ≤ 3.0 times the upper limit of normal for subjects with normal liver.

AST (SGOT) and ALT (SGPT) ≤ 5.0 times the upper limit of normal for subjects with liver metastasis.

Acceptable renal function: a. Creatinine clearance greater than or equal to 60 mL/min (using the Cockcroft-Gault Equation).

Acceptable hematologic functioning (without hematologic support):

ANC ≥ 1000 cells μL.

Platelet count ≥ 75,000/μL.

Hemoglobin ≥ 9.0 g/dL.

All women of childbearing potential must have a negative serum pregnancy test at screening. Male and female subjects must agree to use effective means of contraception (for example, surgical sterilization or the use of barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel or an IUD) with their partner from entry into the study through 6 months after the last dose.

Normal CSF flow and distribution by an accepted CSF flow study (e.g., 111Indium-DTPA or acceptable substitute) before first treatment with the study drug, based on study imaging interpretation and clinical correlation.

Corticosteroids are permitted as clinically indicated.

Exclusion Criteria

The subject has not recovered to the current National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE v5.0) Grade ≤1 from adverse events (AEs) due to antineoplastic agents, investigational drugs, or other medications that were administered prior to study, at time of study registration. a. Prior AEs due to alopecia, anemia, neutropenia, and lymphopenia are not required to be recovered to Grade ≤1 prior to study registration, assuming other inclusion criteria are satisfied.

Contraindications to the placement of an intraventricular catheter (i.e., Ommaya reservoir.)

Presence of or need for a Ventriculo-peritoneal or ventriculo-atrial shunt.

Females of childbearing potential who are pregnant, breastfeeding, or may possibly be pregnant, without a negative serum pregnancy test (see inclusion criteria).

Serious intercurrent illnesses, which could interfere with the planned treatment schedule.

Patients who had any therapeutic radiation dose to the whole brain regardless of when the radiation treatment was delivered, except:

Prior radiation dose to the spinal cord and/or cauda equina is allowed if the equivalent dose in 2 Gy fractions (EQD2) was ≤ 30 Gy to the spinal cord and/or cauda equina using α/β ratio of 3 and if prior radiotherapy has been \> 14 days and ≤ 6 months, or was ≤45 Gy to the spinal cord and/or cauda equina using α/β ratio of 3 and if prior radiotherapy has been \> 6 months.

Prior stereotactic radiosurgery (SRS) to the brain or partial brain radiotherapy is allowed if the equivalent dose in 2 Gy fractions (EQD2) was ≤ 30 Gy to brainstem and/or optic structures (optic nerves, optic chiasm) using α/β ratio of 3 and if prior radiotherapy has been \> 14 days and ≤ 6 months, or was ≤ 45 Gy to the brainstem and/or optic structures (optic nerves, optic chiasm) using α/β ratio of 3 and if prior radiotherapy has been \> 6 months.

Prior or concurrent therapy: a. Intrathecally delivered therapy: i. Concurrent: Concurrent intrathecal therapy. ii. Prior: Intrathecal therapy given less than 14 days before study registration. b. Systemically delivered therapy: i. Concurrent: Systemically delivered therapy UNLESS LM develops while on systemically delivered therapy AND the systemically delivered therapy is NOT associated with more than grade 1 myelosuppression. ii. Prior: Systemically delivered therapy given less than 28 days before study registration.

Projected survival of less than 60 days.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in San Antonio?

Yes, this clinical trial (NCT07098806) has an active research site in San Antonio, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Leptomeningeal Metastasis Treatment Options in San Antonio, TX

If you're searching for leptomeningeal metastasis treatment options in San Antonio, TX, this clinical trial (NCT07098806) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our San Antonio research site is actively enrolling participants for this clinical trial. You'll receive care from experienced leptomeningeal metastasis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all leptomeningeal metastasis clinical trials near you to find additional studies recruiting in your area.

Leptomeningeal Metastasis Clinical Trial in San Antonio, TX

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