NCT07532603 · Priovant Therapeutics, Inc.
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
(ALPINE)
What this study is about
This study will evaluate the clinical safety and effectiveness of taken by mouth brepocitinib in participants with lichen planopilaris
View original scientific description
This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with lichen planopilaris
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age ≥ 18 years
- Scalp biopsy consistent with LPP
- Active and symptomatic LPP at screening and baseline-
- Weight \> 40 kg to \< 130 kg with BMI ≤ 45 kg/m2
Exclusion criteria
- History of: Lymphoproliferative disorder; Active malignancy; History of cancer within 5 years prior to baseline (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid cancer).
- High risk of thrombosis or cardiovascular disease
- High risk of herpes zoster
- Active or recent infection
Where
- Birmingham, Alabama
- Phoenix, Arizona
- Scottsdale, Arizona
- Irvine, California
- Oakland, California
- Sacramento, California
- San Francisco, California
- Denver, Colorado
- Farmington, Connecticut
- New Haven, Connecticut
- Miami, Florida
- Chicago, Illinois
And 33 more locations — see the full list below.
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 8, 2026 · Source of record for eligibility and locations