Is NCT06130280 recruiting in Montvale, NJ?

Yes, NCT06130280 is currently recruiting participants at its Montvale, NJ location. This liver metastasis clinical trial is actively enrolling qualified participants.

How do I join the liver metastasis clinical trial in Montvale?

To join this clinical trial in Montvale, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Montvale clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Liver Metastasis Clinical Trial in Montvale, NJ

About This Liver Metastasis Study in Montvale

The researchers are doing this study to see if one session of high-dose contrast-enhanced MRI-guided SBRT (stereotactic body radiation therapy) is effective for colorectal cancer that has spread to the liver. The researchers will evaluate how well the study treatment can prevent the liver metastasis from growing and spreading. In addition, they will see whether it causes any side effects and whether there are any characteristics of the research MRI images that can predict response to treatment.

Sponsor: Memorial Sloan Kettering Cancer Center

Who Can Participate

Inclusion Criteria

Histologically confirmed colorectal carcinoma and evidence of liver metastasis on imaging

\<=3 liver lesions measurable on contrast enhanced diagnostic MRI with combined size (sum of longest diameters) \< 7 cm, and individual size \< 5cm. (Subsequent simulation scans will not be used for eligibility assessment. In case of significant change in size exceeding 1cm, the individual participants can continue on the protocol provided all normal tissue contraints are met during planning).

Lesion location at least ≥ 2 cm of main, right and left portal vein on the baseline diagnostic MRI. (Subsequent simulation scans will not be used for eligibility assessment. In case of significant change in the distance between the lesion edge and critical structure exceeding 1cm, the individual participants can continue on the protocol provided all normal tissue contraints are met during planning ).

Lesion location at least ≥ 1.5 cm of luminal gastrointestinal tract (stomach, small and large bowel). (Subsequent simulation scans will not be used for eligibility assessment. In case of significant change in the distance between the lesion edge and critical structure exceeding 1cm, the individual participants can continue on the protocol provided all normal tissue contraints are met during planning).

Lesion location ≥ 0.5 cm of diaphragm

Preserved liver function as defined by:

Albumin \> 2 g/dl

\< AST/ ALT ≤ 5 x ULN

Total Bilirubin ≤ 1.5 x UL

Negative serum pregnancy test within 14 days prior to simulation and MRgRT for women of childbearing potential

Any prior systemic or hepatic artery intraarterial pump (HAIP) chemotherapy is permitted with a washout of 2 weeks

Any prior treatment with FDA-approved or investigational biologics or novel molecularly targeted therapies, including oral or IV formulations, are permitted with a washout of 1 weeks or 4 half-lives, which ever is longer

Extrahepatic disease outside the liver is permitted

Prior liver resection is permitted provided there is enough liver parenchyma to meet normal tissue contraints

Prior liver-directed RT is permitted provided departmental normal tissue constraints for re-irradiation can be met

Review by HBP DMT prior to enrollment

Exclusion Criteria

Any history of cirrhosis

History of hepatic radioembolization or selective internal radiation therapy (SIRT)

History of inflammatory bowel disease that precludes liver RT (at the discretion of the treating radiation oncologist).

Current pregnancy or breastfeeding

Men or women not using effective contraception.

Contraindication to or inability to undergo an MR scan, including, but not limited to the history of MR unsafe implants, any implanted cardiac pacemakers or deffibrilators, history of claustrophobia, and contraindications to Gd-EOB-DTPA contrast agent.

Concurrent anti-neoplastic therapy of any kind defined as receipt within 1 week of RT administration

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Montvale?

Yes, this clinical trial (NCT06130280) has an active research site in Montvale, NJ that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Liver Metastasis Treatment Options in Montvale, NJ

If you're searching for liver metastasis treatment options in Montvale, NJ, this clinical trial (NCT06130280) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Montvale research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced liver metastasis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all liver metastasis clinical trials near you to find additional studies recruiting in your area.

Liver Metastasis Clinical Trial in Montvale, NJ

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