Baltimore, MDNCT06521554Now EnrollingIRB Ready

Locally Advanced Solid Tumor Clinical Trial in Baltimore, MD

Access cutting-edge locally advanced solid tumor treatment through this clinical trial at a research site in Baltimore. Study-provided care at no cost to qualified participants.

Sponsored by Nuvalent Inc.

Quick Self-Assessment

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Expert Care in Baltimore

Access locally advanced solid tumor specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related locally advanced solid tumor treatment provided free

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Check if you qualify for this locally advanced solid tumor clinical trial in Baltimore, MD

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Why Participate?

  • No-Cost Study Care

  • Local to Baltimore

    Convenient for MD residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Baltimore site if eligible
  4. 4Begin participation

About This Locally Advanced Solid Tumor Study in Baltimore

Phase 1a/1b dose escalation and expansion study designed to evaluate the safety and tolerability of NVL-330, determine the recommended Phase 2 dose (RP2D), and evaluate the antitumor activity in participants with advanced or metastatic human epidermal growth factor receptor 2 (HER2) -altered non-small lung cancer (NSCLC). Phase 1a dose escalation is designed to assess the safety and tolerability of NVL-330 and to select the candidate RP2D(s) and, if applicable, the MTD. Phase 1b expansion is designed to further evaluate the overall safety and tolerability of the candidate RP2D(s) of NVL-330 and to determine the RP2D of NVL-330 in participants with advanced or metastatic HER2 mutant NSCLC.

Sponsor: Nuvalent Inc.

Who Can Participate

Inclusion Criteria

Age ≥ 18 years
Histologically or cytologically confirmed locally advanced or metastatic NSCLC
Documented HER2 status as follows:
Phase 1a: Documented oncogenic HER2 mutation such as HER2 exon20 insertion mutations or single nucleotide variants or HER2 amplification.
Phase 1b: Documented oncogenic HER2 mutation.
Identification of lesions as follows:
Phase 1a: Must have evaluable disease (target or nontarget) according to RECIST 1.1.
Phase 1b: Must have measurable disease, defined as ≥ 1 radiologically measurable target lesion according to RECIST 1.1.
Adequate organ function and bone marrow reserve

Exclusion Criteria

Participant's cancer has known oncogenic driver alteration other than HER2
Known allergy/hypersensitivity to excipients of NVL-330
Major surgery within 4 weeks of the first dose of study drug
Ongoing or recent anticancer therapy
Actively receiving systemic treatment or direct medical intervention on another therapeutic clinical study

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Baltimore?

Yes, this clinical trial (NCT06521554) has an active research site in Baltimore, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Locally Advanced Solid Tumor Treatment Options in Baltimore, MD

If you're searching for locally advanced solid tumor treatment options in Baltimore, MD, this clinical trial (NCT06521554) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Baltimore research site is actively enrolling participants for this clinical trial. You'll receive care from experienced locally advanced solid tumor specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all locally advanced solid tumor clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Baltimore, MD