Is NCT07277582 recruiting in Boston, MA?

Yes, NCT07277582 is currently recruiting participants at its Boston, MA location. This long qt syndrome (lqts) 2 clinical trial is actively enrolling qualified participants.

How do I join the long qt syndrome (lqts) 2 clinical trial in Boston?

To join this clinical trial in Boston, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Boston clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Long QT Syndrome (LQTS) 2 Clinical Trial in Boston, MA

About This Long QT Syndrome (LQTS) 2 Study in Boston

The goal of this clinical trial is to learn whether the study drug THRV-1268 can safely and effectively shorten the QT interval in people diagnosed with Long QT Syndrome Type 2 (LQTS 2). The study will also learn about the safety and tolerability of THRV-1268 at different doses. The main questions this study aims to answer are: Does THRV-1268 reduce the QTc interval (a measure of the heart's electrical recovery time)? What side effects or medical problems occur when participants take THRV-1268? Which dose of THRV-1268 works best and is safest? Participants will: Complete a 3-week observation period with ECG and Holter monitoring to establish baseline QTc measurements Take THRV-1268 tablets twice daily at two dose levels for 6 weeks (Part A) or be randomly assigned to a dose group for 6 weeks (Part B) Have clinic visits and tests to monitor safety and changes in their heart rhythm May continue taking THRV-1268 for up to 1 year for ongoing safety and efficacy evaluation Researchers will compare changes in QTc over time and evaluate side effects to determine whether THRV-1268 can help reduce the risk of abnormal heart rhythms and sudden cardiac events in people with LQTS 2.

Sponsor: Thryv Therapeutics, Inc.

Who Can Participate

Inclusion Criteria

Male and female participants over 15 years of age at Screening (at least the first 5 participants enrolled in Part A must be 18 years of age or older).

LQTS 2 genotype: Demonstration of KCNH2 mutation by clinical laboratory test result that is autosomal dominant (heterozygous) and considered to be pathologic or likely pathologic can be included after approval from the sponsor medical monitor or qualified delegate.

QTcF interval \>480 ms and ≤600 ms based on Screening ECG.

Body weight of at least 45 kg with body mass index between 18.0 and 40.0 kg/m2, inclusively at Screening.

Male and female participants of childbearing potential must agree to use highly effective contraception throughout the duration of the study.

Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.

Participants age 15 to \<18 years capable of providing signed assent.

Exclusion Criteria

Within 2 months prior to Screening, Participant has a history of an aborted cardiac arrest, ICD implantation, or syncopal episode due to a ventricular arrhythmia. Participants can be enrolled after the 2-month period has lapsed.

History of structural or functional cardiovascular disease, myocardial infarction or stroke or transient ischemic attack (TIA), atrial fibrillation or atrial flutter, heart failure, bundle branch block, angina pectoris, or hemodynamically significant ventricular tachycardia not due to TdP

Active or known liver disease.

Active or past oncologic disease, except for non-melanoma skin cancer.

Advanced pulmonary disease that requires more than a steroid inhaler.

Pulmonary artery hypertension.

Is pregnant, lactating, or breastfeeding, or planning to become pregnant.

Has a positive result for the urine pregnancy test at the Screening Visit or the serum pregnancy test at the Day -7 Visit.

Clinically significant abnormal findings on the physical examination or medical history during Screening or Day -21 as deemed by the investigator.

Has experienced an acute illness that has resolved in less than 14 days before the first study drug dose or has had a major illness or hospitalization within 1 month before the first study drug dose.

Has a recent history of alcohol or substance abuse that would pose a risk for the participant's safety and compliance with the study protocol, in the opinion of the investigator.

Has a pacemaker or ICD that is actively used for ventricular pacing.

Is currently taking or anticipates the use of any restricted drugs

Is considering or scheduled to undergo any elective surgical procedure during the study.

Current participation or recent within 1 month of participating in another interventional clinical study.

Screening Visit diastolic blood pressure \>95 mm Hg, systolic blood pressure \<90 or \>150 mm Hg.

At Screening, if the 12-lead triplicate ECG demonstrates any of the following: PR \>280 ms; QRS \>110 ms, or QTcF \>600 ms or ≤480 ms; bundle branch block or significant ST-T wave abnormalities or flat T waves that could interfere with QT analysis. HR \<50 bpm, unless receiving a beta-blocker in which case \<40 bpm, or HR \>100 bpm at rest.

Atrial pacing rate set to \>80 bpm in those participants with atrial pacing.

Abnormal renal function with an eGFR of \<70 mL/min/1.73 m2 (with eGFR calculated by the CKD-EPI formula at Screening). One retest of the exclusionary eGFR value is allowed at the discretion of the investigator.

Has abnormal liver function tests:

ALT, AST, GGT, ALP \> 1.5 the ULN.

Total bilirubin \>ULN.

INR \>1.2 ULN (requires measurement of prothrombin time (PT)).

Has clinically significant abnormality in serum chemistry values at Screening for hemoglobin, potassium, magnesium, or calcium levels as determined by the investigator. A single repeat test and/or correction of abnormal values (e.g., electrolyte repletion) is permitted at the investigator's discretion prior to enrollment.

Any participant, who, for any reason, is deemed by the investigator to be inappropriate for this study or has any condition which would confound or interfere with the evaluation of the safety, tolerability, or efficacy of the investigational medicinal product (IMP) or prevent compliance with the study protocol.

Consumes on average more than 21 standard alcoholic drinks per week in men and 14 standard drinks per week in women over the last 2 years.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT07277582) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Long QT Syndrome (LQTS) 2 Treatment Options in Boston, MA

If you're searching for long qt syndrome (lqts) 2 treatment options in Boston, MA, this clinical trial (NCT07277582) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced long qt syndrome (lqts) 2 specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all long qt syndrome (lqts) 2 clinical trials near you to find additional studies recruiting in your area.

Long QT Syndrome (LQTS) 2 Clinical Trial in Boston, MA

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