NCT06122077 · Freenome Holdings Inc.
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
(PROACT-LUNG)
What this study is about
The PROACT LUNG study is a forward-looking multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine, standard-of-care screening Low-Dose Computed Tomography (LDCT).
View original scientific description
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine, standard-of-care screening Low-Dose Computed Tomography (LDCT).
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age 50 years or older within 30 days of enrollment
- Current or former smokers with a cumulative smoking history of ≥ 20 pack-year
- Able to comprehend and willing to sign and date the informed consent and HIPAA authorization documents
Exclusion criteria
- Any active therapy for cancer, including but not limited to surgery, chemotherapy, biologic therapy, immunotherapy, and/or radiation therapy at the time of enrollment
- History of any malignancy within prior 5 years of enrollment (except for non- melanoma skin cancer)
- History of organ, tissue, and bone marrow transplantation
- Screened for lung cancer or having chest CT scan 12 months before enrollment
- Having signs and symptoms of lung cancer such as hemoptysis, superior vena cava syndrome, Cushing syndrome, and Pancoast syndrome
- Received a blood transfusion in the 30 days preceding enrollment
- Known to be pregnant
- Participated or currently participating in another Freenome-sponsored clinical study
- Participated or currently participating in a clinical research study in which an experimental medication has been administered during the 60 days preceding enrollment
- Any condition that in the opinion of the Investigator should not be enrolled in the study
Where
- Los Angeles, California
- Stamford, Connecticut
- DeLand, Florida
- Doral, Florida
- Kissimmee, Florida
- Port Orange, Florida
- The Villages, Florida
- Winter Park, Florida
- Gainesville, Georgia
- Chicago, Illinois
- Deerfield, Illinois
- Springfield, Illinois
And 24 more locations — see the full list below.
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 5, 2025 · Source of record for eligibility and locations