NCT00280202 · University of Pittsburgh
Detection of Genetic Markers of Lung Cancer
What this study is about
The purpose of this research study is to determine the genetic changes and immunologic changes that are involved in the development and progression of bronchogenic lung cancer.
View original scientific description
The purpose of this research study is to determine the genetic changes and immunologic changes that are involved in the development and progression of bronchogenic lung cancer.
Interventions
PROCEDURE
Biopsy of the major carinal area
Biopsy performed intraoperatively
PROCEDURE
Biopsy of abnormal & suspicious areas of the bronchial tree
Biopsy performed intraoperatively
PROCEDURE
Evaluation of the tumor for DNA mutations
Tumor tissue is banked for future analysis.
PROCEDURE
Bronchoalveolar Lavage (BAL) for cytokine analysis
BAL performed intraoperatively
PROCEDURE
Correlation of flow cytometric & RT PCR for TNM stage
Tissues banked for future correlative studies
PROCEDURE
Analysis of lymph nodes
Tissues banked for future analysis
Primary outcome measures
The odds ratio for the risk of lung cancer associated with molecular markers
Time frame: No specific time frame
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Histologic confirmation of lung cancer, lung metastases from a primary site other than lung, mesothelioma or a radiographic lesion highly suspicious for malignancy
- Written informed consent.
- To be scheduled for a biopsy or surgical resection or have already had a biopsy and/or surgical removal of a lung mass
Where
- Pittsburgh, Pennsylvania
Collaborators
National Institutes of Health (NIH)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 24, 2025 · Source of record for eligibility and locations