NCT06810375 · George Washington University
Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery
What this study is about
This clinical trial compares effectiveness in postoperative pain management in thoracic surgery between erector spinae block versus liposomal bupivacaine injections.
View original scientific description
This clinical trial compares efficacy in postoperative pain management in thoracic surgery between erector spinae block versus liposomal bupivacaine injections.
Interventions
DRUG
Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)
preoperative erector spinae block with bupivacaine (Marcaine®)
DRUG
Intercostal nerve block
intraoperative intercostal nerve block with liposomal bupivacaine (Exparel®)
Primary outcome measures
Postoperative pain control assessment
Time frame: Up to 48 hours postoperatively
Study team will assess postoperative pain scores at 6, 12, 24 and 48 hours (Minimum numerical pain score of 0 and a maximum of 10)
Morphine equivalent assessment
Time frame: Up to 72 hours postoperatively
Study team will collect information on all administered pain medications to calculate morphine equivalents
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Video assisted pulmonary resection, pleurodesis or decortication
Exclusion criteria
- Allergy to local anesthetics
- Patient undergoing bilateral surgery
- Surgery is emergent as deemed by the principal investigator
Where
- Washington D.C., District of Columbia
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 9, 2026 · Source of record for eligibility and locations