NCT06925373 · University of Alabama at Birmingham
Housing, Environment, And Living Conditions for Transformed Health
(HEALTHe)
What this study is about
This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each approach.
View original scientific description
This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each approach. STUDY 1: The study will assess the effects of public housing and neighborhood environment (built and social) improvements on health-related behaviors, psychosocial and physiologic stress, and self-reported and physiological markers of lung health and chronic disease. STUDY 2: The study will determine whether indoor air purification can positively impact lung health in public housing sites not undergoing housing renovation, comparing a site near industrial pollution vs one less contaminated.
Interventions
OTHER
Indoor Air Purification
An indoor air purifier with a dual HEPA/activated carbon filter, a usage tracker, and an indoor air quality monitor will be installed in public housing residences.
OTHER
Neighborhood Improvements
Improved built environment (green space, sidewalks, street lights) and social environment (educational and workforce development programs, wrap-around social services, Internet access).
OTHER
Housing Improvements
High-quality public housing
Primary outcome measures
Change in Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health
Time frame: Baseline, 12 months, 24 months
A self-reported measure of physical, mental, and social health. 10 item questionnaire T-score metric from zero to 100 where higher T-scores indicate better health.
Change in Allostatic load
Time frame: Baseline, 12 months
Measure of cumulative stress burden as the number of 10 indicators above a threshold: (1) serum albumin \<3.8 g/dL, (2) C Reactive Protein (CRP) \>3 mg/L, (3) High-Density Lipoprotein (HDL) \<40 mg/dL, (4) total cholesterol ≥240 mg/dL, (5) heart rate ≥90 beats/min, (6) systolic Blood Pressure (BP) ≥140 mmHg, (7) diastolic BP ≥90 mmHg, (8) serum creatinine ≥1.3 mg/dL, (9) Blood Urea Nitrogen (BUN) ≥18 mg/dL, and (10) waist circumference \>88 cm in women, \>102 cm in men.
Change in Indoor Air Quality
Time frame: Baseline, 6 months, 12 months (Study 2 only)
Particulate matter (PM2.5). Measures particles in the air that are 2.5 micrometers or smaller in diameter.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Adults age 18 years and older
- English speaking
- Residents of one of 4 public housing site in Birmingham, Alabama
Exclusion criteria
- Individuals who are not 18 years or older
- Do not speak English
- Do not meet the residency criteria
Where
- Birmingham, Alabama
Collaborators
National Institute of Nursing Research (NINR)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 6, 2026 · Source of record for eligibility and locations