NCT07029009 · Mansa
Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY)
What this study is about
The reason for this research study is to better understand the use of liraglutide, a commonly prescribed Type 2 diabetes medication, in patients with a diagnosis of maturity-onset diabetes of the young (MODY). The investigators are interested in better understanding the way that this drug affects the metabolism and hormone levels of a person with MODY.
View original scientific description
The reason for this research study is to better understand the use of liraglutide, a commonly prescribed Type 2 diabetes medication, in patients with a diagnosis of maturity-onset diabetes of the young (MODY). The investigators are interested in better understanding the way that this drug affects the metabolism and hormone levels of a person with MODY. Many people with MODY report having gastrointestinal (GI) issues such as an upset stomach. Investigators also are interested in finding out if this drug will help with GI issues. If liraglutide does help with this symptom of MODY, the investigators want to know why this happens. If this drug is effective for participants, the investigators will use participants cells to make human induced pluripotent stem cell (iPSC). This means that the investigators will use participant cells to create what are called stem cells, which are cells in the body that are able to be told what their job is. Investigators will use these cells to see what happens in gastrointestinal (GI) tract.
Interventions
DRUG
Liraglutide
Liraglutide will be prescribed following FDA approved packet insert for type 2 diabetes in our test population.
Primary outcome measures
Blood sugar control - HbA1C
Time frame: Baseline and 3 months after study treatment initiation
Hemoglobin A1c
BMI
Time frame: baseline, 1 month, 2 months, and final study visit 3 months after study treatment initiation
Body mass index; weight and height will be combined to report BMI in kg/m\^2
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Diagnosis of MODY via genetic testing
- HgbA1c \>6.5%
Exclusion criteria
- History of anaphylaxis to GLP-1 receptor agonists
- Already taking GLP-1 receptor agonists
- on medications within the stimulant class
- have had bariatric surgery
- personal or family history of cancer, especially medullary thyroid cancer
- personal history of pancreatitis or pathogenic variants associated with increased risk of pancreatitis
- known active kidney disease
- severe hypoglycemia (glucose \< 50 mg/dL) within 3 months of study enrollment
- HbA1c \> 10.0%
- episode of diabetic ketoacidosis (DKA) in the past 3 months
- are currently pregnant
- BMI \< 18.5 kg/m2 and pediatric patients with BMI \< 5th percentile
Where
- Cincinnati, Ohio
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Dec 17, 2025 · Source of record for eligibility and locations