Is NCT05338658 recruiting in Minneapolis, MN?

Yes, NCT05338658 is currently recruiting participants at its Minneapolis, MN location. This metastasis clinical trial is actively enrolling qualified participants.

How do I join the metastasis clinical trial in Minneapolis?

To join this clinical trial in Minneapolis, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Minneapolis clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Metastasis Clinical Trial in Minneapolis, MN

About This Metastasis Study in Minneapolis

This is a single center Phase I study with extension of peptide alarm therapy (PAT) administered by intratumoral (IT) injection during the 1st course of a standard of care intravenous PD-1/PD-L1 inhibitor for the treatment of locally advanced or metastatic solid tumor cancers that has failed to be controlled after one or more prior therapies including a previous PD-1/PD-L1 inhibitor

Sponsor: Masonic Cancer Center, University of Minnesota

Who Can Participate

Inclusion Criteria

Must be seropositive for CMV and EBV.

Must have at least one HLA-A\*0201 allele. This screening can be performed after determining CMV and EBV seropositivity is established or, if available, from the results of previous tumor profiling by any CLIA-certified lab (i.e. Caris, FoundationOne).

18 years or older at the time of signing the pre-screening consent.

ECOG Performance Status 0 or 1.

Adequate organ function within 14 days of study enrollment

Cardiac: New York Heart Association (NYHA) Functional Classification Class I.

Pulmonary: oxygen saturation ≥ 90% on room air.

Time between last dose of prior anti-cancer therapy and Day 1 of this study:

Chemotherapy: a minimum of 28 days since last treatment.

Targeted therapy, immunotherapy, investigational agents: a minimum of 45 days since last dose (at least 2 months for anti-VEGF)

Prior palliative radiotherapy within 7 days of start of study treatment. Participants must have recovered from all radiation-related toxicities (prior irradiation to targeted lesions is not permitted)

Must have recovered to CTCAE ≤Grade 1 from previous treatment related acute toxicities.

Persons of childbearing potential or with partners of childbearing potential must be willing to abstain from heterosexual activity or to use a highly effect form of contraception from the time of study enrollment until at least 4 months after the last dose of PD-1/PD-L1 inhibitor.

Able to understand and provide voluntary written consent prior to the performance of any research related activity.

Exclusion Criteria

Pregnant or breast feeding.

Requires therapeutic anticoagulation for which it is deemed unsafe to discontinue anticoagulation for 5 days prior to Cycle 1 through Day 7 of Cycle 1

Class II or greater New York Heart Association Functional Classification criteria or serious cardiac arrhythmias likely to increase the risk of cardiac complications of therapy (e.g. ventricular tachycardia, frequent ventricular ectopy, or supraventricular tachyarrhythmia requiring chronic therapy)

Known active CNS metastases

Has active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs).

Has received a live vaccine within 30 days prior to the first dose of study drug.

Diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to study enrollment.

Prior bone marrow and/or solid organ transplant.

Has severe hypersensitivity (≥Grade 3) to prior PD-1/PD-L1 and/or any of its excipients.

Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis.

Has an active infection requiring systemic therapy.

Known seropositive for HIV or known active Hepatitis B or C infection with detectable viral load by PCR

Known history of active TB (Bacillus Tuberculosis)

Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment.

Has uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, interstitial lung disease, non-infectious pneumonitis, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements in the opinion of the treating investigator.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Minneapolis?

Yes, this clinical trial (NCT05338658) has an active research site in Minneapolis, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Metastasis Treatment Options in Minneapolis, MN

If you're searching for metastasis treatment options in Minneapolis, MN, this clinical trial (NCT05338658) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Minneapolis research site is actively enrolling participants for this phase 1 clinical trial. You'll receive care from experienced metastasis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all metastasis clinical trials near you to find additional studies recruiting in your area.

Metastasis Clinical Trial in Minneapolis, MN

Expert Care in Minneapolis

IRB Approved

No-Cost Care

Apply for This Minneapolis Location

Why Participate?

Simple Process