Zion, ILNCT07403721Now EnrollingIRB Ready

Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR) Clinical Trial in Zion, IL

Access cutting-edge metastatic or locally advanced solid tumors with microsatellite instability-high (msi-h) or mismatched repair deficiency (dmmr) treatment through this clinical trial at a research site in Zion. Study-provided care at no cost to qualified participants.

Sponsored by Amgen

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Expert Care in Zion

Access metastatic or locally advanced solid tumors with microsatellite instability-high (msi-h) or mismatched repair deficiency (dmmr) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related metastatic or locally advanced solid tumors with microsatellite instability-high (msi-h) or mismatched repair deficiency (dmmr) treatment provided free

Apply for This Zion Location

Check if you qualify for this metastatic or locally advanced solid tumors with microsatellite instability-high (msi-h) or mismatched repair deficiency (dmmr) clinical trial in Zion, IL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Zion

    Convenient for IL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Zion site if eligible
  4. 4Begin participation

About This Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR) Study in Zion

The primary objectives of this trial are to evaluate the safety profile of AMG 436 and to determine the maximum tolerated dose (MTD) and/or the recommended dose for AMG 436 as monotherapy and in combination with other anti-cancer therapies in participants with MSI-H/dMMR solid tumors.

Sponsor: Amgen

Who Can Participate

Inclusion Criteria

Age ≥ 18 years (or ≥ legal age within the country if it is older than 18 years).
Histologically confirmed MSI-H or dMMR metastatic or locally advanced solid tumor by local testing or central testing.
Tumor tissue (formalin-fixed, paraffin-embedded sample) archival block must be available. Participants without archived tumor tissue may enroll by undergoing tumor biopsy before dosing.
Disease measurable as defined by Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1).
Eastern Cooperative Oncology Group performance (ECOG) 0-1.
Adequate organ function as defined in the protocol.

Exclusion Criteria

Participants with primary central nervous system (CNS) tumors.
Impaired cardiac function or clinically significant cardiac disease.
Major surgery within 28 days of trial day 1.
Antitumor therapy (chemotherapy, antibody therapy, molecular targeted therapy, hormonal therapy, or investigational agent) within 21 days of first dose of trial treatment, unless anti-tumor therapy is a therapy with 5 times the half-life being shorter than 21 days (in this case, enrollment may be allowed with washout from prior therapy of \< 21 days.
Radiation therapy within 28 days of the first dose of trial treatment (or local or focal radiotherapy with palliative intent within 14 days of the first dose).
Gastrointestinal tract disease causing the inability to take per os (PO) medication, malabsorption syndrome, requirement for intravenous (IV) alimentation, uncontrolled inflammatory gastrointestinal disease (eg, Crohn's disease, ulcerative colitis).

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Zion?

Yes, this clinical trial (NCT07403721) has an active research site in Zion, IL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR) Treatment Options in Zion, IL

If you're searching for metastatic or locally advanced solid tumors with microsatellite instability-high (msi-h) or mismatched repair deficiency (dmmr) treatment options in Zion, IL, this clinical trial (NCT07403721) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Zion research site is actively enrolling participants for this clinical trial. You'll receive care from experienced metastatic or locally advanced solid tumors with microsatellite instability-high (msi-h) or mismatched repair deficiency (dmmr) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all metastatic or locally advanced solid tumors with microsatellite instability-high (msi-h) or mismatched repair deficiency (dmmr) clinical trials near you to find additional studies recruiting in your area.

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