Dallas, TXNCT07361874Now EnrollingIRB Ready

Mild Autonomous Cortisol Secretion (MACS) Clinical Trial in Dallas, TX

Access cutting-edge mild autonomous cortisol secretion (macs) treatment through this clinical trial at a research site in Dallas. Study-provided care at no cost to qualified participants.

Sponsored by University of Texas Southwestern Medical Center

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Expert Care in Dallas

Access mild autonomous cortisol secretion (macs) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related mild autonomous cortisol secretion (macs) treatment provided free

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Check if you qualify for this mild autonomous cortisol secretion (macs) clinical trial in Dallas, TX

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Why Participate?

  • No-Cost Study Care

  • Local to Dallas

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Dallas site if eligible
  4. 4Begin participation

About This Mild Autonomous Cortisol Secretion (MACS) Study in Dallas

The goal of this study is to learn how two treatments-adrenalectomy (surgical removal of an adrenal gland) and semaglutide (a medication used for weight management)-affect insulin resistance and cortisol regulation in adults with mild autonomous cortisol secretion (MACS). The study will also learn how these treatments impact body composition, blood pressure, cholesterol, inflammation, muscle strength, and quality of life. The main questions the study aims to answer are: 1. Does adrenalectomy or semaglutide improve insulin resistance more in people with MACS? 2. How do these treatments change cortisol patterns and other cardiometabolic risk factors? 3. Do people with MACS respond differently to semaglutide compared to matched adults without MACS? Participants will: 1. Receive either adrenalectomy or semaglutide if they have MACS, or semaglutide if they are matched controls 2. Complete clinic visits and phone visits over about 26-30 weeks 3. Undergo metabolic testing such as blood tests, urine steroid profiling, body composition scans, blood pressure monitoring, muscle strength testing, and questionnaires about health and well-being

Sponsor: University of Texas Southwestern Medical Center

Who Can Participate

Inclusion Criteria

Adults ≥18 years
MACS groups: adrenal adenoma + DST cortisol \>1.8 µg/dL + no overt Cushing + eligible for adrenalectomy
Willingness to postpone surgery 6 months if randomized
Controls: no adrenal abnormalities + normal DST + BMI ≥27 + ≥2 cardiometabolic conditions
Stable medication doses for ≥4 weeks
Negative pregnancy test if applicable

Exclusion Criteria

Prior GLP-1 RA within 90 days
Weight change \>5 kg in past 90 days
Prior obesity/diabetes surgery
Type 1 diabetes or other diabetes types
Severe organ disease
Recent pancreatitis
Pregnancy, breastfeeding
Contraindication to semaglutide
Contraindication to surgery delay
Chronic glucocorticoid use

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Dallas?

Yes, this clinical trial (NCT07361874) has an active research site in Dallas, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Mild Autonomous Cortisol Secretion (MACS) Treatment Options in Dallas, TX

If you're searching for mild autonomous cortisol secretion (macs) treatment options in Dallas, TX, this clinical trial (NCT07361874) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Dallas research site is actively enrolling participants for this clinical trial. You'll receive care from experienced mild autonomous cortisol secretion (macs) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all mild autonomous cortisol secretion (macs) clinical trials near you to find additional studies recruiting in your area.

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