Rochester, MNNCT07104812Now EnrollingIRB Ready

Mild Autonomous Cortisol Secretion Clinical Trial in Rochester, MN

Access cutting-edge mild autonomous cortisol secretion treatment through this clinical trial at a research site in Rochester. Study-provided care at no cost to qualified participants.

Sponsored by Mayo Clinic

Quick Self-Assessment

See if you qualify for this Rochester location

Preparing your pre-screening questions…

Expert Care in Rochester

Access mild autonomous cortisol secretion specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related mild autonomous cortisol secretion treatment provided free

Apply for This Rochester Location

Check if you qualify for this mild autonomous cortisol secretion clinical trial in Rochester, MN

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Rochester

    Convenient for MN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Rochester site if eligible
  4. 4Begin participation

About This Mild Autonomous Cortisol Secretion Study in Rochester

The purpose of this study is to evaluate the safety and tolerability of 1 mg osilodrostat therapy in patients with mild autonomous cortisol secretion (MACS), and to determine the impact on 24h urine steroid metabolome and circadian cortisol/cortisone concentrations

Sponsor: Mayo Clinic

Who Can Participate

Inclusion Criteria

Provide written informed consent
Stated willingness to comply with all study procedures and availability for the duration of the study
Age ≥ 18 years
Diagnosed with MACS
At least 2 abnormal post-dexamethasone cortisol results: i. 1 mg post-dexamethasone cortisol \>1.8 mcg/dL or ii. 8 mg post-dexamethasone cortisol \>1 mcg/dL
Historical dexamethasone suppression test results can be used if performed within 24 months prior to enrollment.
Adrenal imaging phenotype consistent with benign disease (adrenal adenoma/s, macronodular or micronodular adrenal hyperplasia)
At least one of the following comorbidities:
Obesity (BMI\>30 kg/m2)
Dysglycemia
Dyslipidemia
Hypertension
Osteoporosis
Fragility fractures
Ability to take oral medication and be willing to adhere to the study intervention regimen
For persons of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use a contraceptive method with a failure rate of ≤ 5% per year during the treatment period and for 1 month after the last dose of study treatment.

Exclusion Criteria

Planned alternative therapy for MACS during the study period
Current use of oral exogenous glucocorticoid therapy
Current use of opioid therapy \>20 MME/day
Planned use of oral exogenous glucocorticoid therapy
Planned use of opioid therapy \>20 MME/day
Use of injectable glucocorticoid within the last 6 weeks or anticipated glucocorticoid use during the study period.
Hypokalemia of hypomagnesemia at baseline visit
Prolonged QTc on baseline ECG
Concomitant therapy with medications likely to lead to drug-drug interactions (based on PI review).
Investigator's judgement based on history/physical examination that a comorbidity or concomitant medication may impact the hypothalamic-pituitary-adrenal axis or steroid metabolome
Uncontrolled intercurrent illness including, but not limited to:
Ongoing or active infection
Symptomatic congestive heart failure
Unstable angina pectoris
Cardiac arrhythmia
Psychiatric illness/social situations that would limit compliance with study requirements
Pregnancy or lactation
Known allergic reactions to osilodrostat
Suspected false positive post-dexamethasone cortisol results due to increased metabolism, poor absorption, or noncompliance with dexamethasone.
Treatment with another investigational drug or other intervention within lower than specific therapy washout period

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Rochester?

Yes, this clinical trial (NCT07104812) has an active research site in Rochester, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Mild Autonomous Cortisol Secretion Treatment Options in Rochester, MN

If you're searching for mild autonomous cortisol secretion treatment options in Rochester, MN, this clinical trial (NCT07104812) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Rochester research site is actively enrolling participants for this clinical trial. You'll receive care from experienced mild autonomous cortisol secretion specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all mild autonomous cortisol secretion clinical trials near you to find additional studies recruiting in your area.

More Heart Attack Trials in Rochester, MN

See all heart attack clinical trials recruiting in Rochester — not just this study.

Browse Heart Attack Trials in Rochester →

Browse More Trials by Condition

Heart Attack TrialsEssential Tremor TrialsMyocardial Infarction TrialsInterstitial Lung Disease TrialsAll Conditions →

Ready to Join in Rochester?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Rochester, MN