NCT06453980 · University of Michigan
Multimodal Investigation of Neural Plasticity
(miniSTIM)
What this study is about
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).
View original scientific description
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).
Interventions
DEVICE
sham tDCS
Participants will receive sham (placebo) HD-tDCS for 20 minutes, for 1 session.
DEVICE
active tDCS
Participants will receive HD-tDCS at 3 milliAmp for 20 minutes, for 1 session.
Primary outcome measures
Changes in glutamate concentration (fMRS)
Time frame: average on 1 week
Analyses via fMRS using units of concentration
Changes in brain activation (fMRI)
Time frame: average of 1 week
Analyses via fMRI using units of brain activation
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Normal cognition for HC and diagnosis of Mild Cognitive Impairment (MCI) for MCI participants
- Right-handedness
- Magnetic resonance compatible, criteria that also apply for high definition transcranial direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants in the upper body or head)
Exclusion criteria
- History of other contributing neurological or medical conditions known to affect cognitive functioning
- Significant mental illness
- Sensory impairments that limit ability to participate
- History of alcohol or drug abuse/dependence
Where
- Ann Arbor, Michigan
Collaborators
Alzheimer's Association, Wayne State University
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 10, 2026 · Source of record for eligibility and locations