Is NCT07271485 recruiting in Littleton, CO?

Yes, NCT07271485 is currently recruiting participants at its Littleton, CO location. This misophonia clinical trial is actively enrolling qualified participants.

How do I join the misophonia clinical trial in Littleton?

To join this clinical trial in Littleton, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Littleton clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Misophonia Clinical Trial in Littleton, CO

About This Misophonia Study in Littleton

The primary goal of this study is to investigate whether a one-time dose of 20 mg oral propranolol can temporarily reduce the adverse emotional and physical symptoms triggered by misophonia. The secondary goals of this study are: 1. Determine potential predictors of response to propranolol treatment, including demographic factors, baseline symptom severity, psychometric instrument item responses, and physiological characteristics. 2. Evaluate the safety and tolerability of propranolol in individuals with misophonia.

Sponsor: Bloom Mental Health, LLC

Who Can Participate

Inclusion Criteria

Able to complete study visit(s) in Littleton, CO.

Able to give informed consent.

Participant reports clinically significant misophonia symptoms, as determined by answers on the standardized "Misophonia Trigger Screening Questions for Participants" form (described separately in the protocol). Specifically, participants must demonstrate relevant misophonia trigger responses that meet pre-specified minimum severity criteria detailed on this form.

A-MISO-S rating scale severity criterion: Participants must score at least a moderate ("2") or higher on question 2 and question 3 of the Amsterdam Misophonia Scale (A-MISO-S) at screening, since this indicates clinically meaningful misophonia severity for study eligibility.

Able to communicate misophonic distress in writing and reasonably participate in our outpatient clinical setting, meaning able to tolerate being in this outpatient clinical setting, follow the clinic rules for all patients and guests, and respond in an understandable fashion to questions administered to them.

Must agree to follow study clinician advice and seek additional care outside of this clinic if advised (e.g., if advised to seek help from emergency services for a potentially serious adverse reaction).

English fluency

Exclusion Criteria

Current use of scheduled propranolol for any condition.

Any of the known contraindications for taking propranolol:

cardiogenic shock

sinus bradycardia (\<50 bpm)

greater than first degree heart block

BP below 90/60

asthma / bronchial asthma that requires treatment or medication, and/or has caused clinical concerns within the last 5 years

Other heart conditions that require ongoing medical treatment

Participants with any of the following relative contraindications for taking propranolol:

participants who have active anorexia, purging, or who are underweight (\<18.5 BMI)

Active drug or alcohol use within the last 48 hours prior to study participation, or active drug withdrawals

A history of untreated diabetes or other endocrine disorders that could be harmed by exposure to propranolol

history of cardiovascular disease or stroke, or symptomatic blood disorders such as anemia

history of any other severe physical or neurological conditions that may affect their ability to participate in the study

Participants with liver or kidney disease that would be affect or be affected by the study drug

Participants may, depending on the circumstances as decided by the study clinician, be excluded for any of the following conditions that may have adverse reactions to propranolol, including: Raynaud disease or other peripheral vascular disease, Pheochromocytoma, Psoriasis, Thyroid disease (untreated, and affected by propranolol), Unexplained dizziness, Oxygen level below 91%, Respirations below 12 or above 20

Participants taking any other medications that could interfere with the effects of propranolol, as determined by the study clinician (e.g. other beta blockers, alpha blockers,prazosin, clonidine, guanfacine, diuretics, calcium channel blockers, acute us of anti-anxiety medications; other medications that interfere with the adrenergic system; or medications that have a significant effect on propranolol's pharmacology that would normally affect dosing in clinical practice

Allergy or sensitivity to propranolol, placebo ingredients, and/or capsule ingredients.

Pregnant or nursing.

Any of the following in 30 days prior to enrollment: active psychosis, suicidal/ self-harming / homicidal thoughts, bipolar mania, panic attacks, traumatic dissociation, Post-Traumatic Stress Disorder (PTSD) flashbacks, or psychiatric hospitalization.

Participant self-reports or clinical interview identifies any misophonia-triggered reactions within the past year that posed a significant risk to health or safety, including suicidal or homicidal ideation, or uncontrolled physical behaviors (e.g., self-injury, aggression toward others, throwing objects, screaming, or fleeing uncontrollably). This criterion is assessed via direct structured questioning during participant screening interviews and review of participant self-reports on standardized screening questionnaires.

Misophonia trigger symptoms are determined by a medical provider to be better explained by a condition other than Misophonia, such as hyperacusis or phonophobia.

Inability to hear routine sounds and communication (ie severe hearing impairment), only if it interferes with ability to hear the misophonia triggers on the video.

Participants who are triggered by the sound of water running or a car alarm (our control videos)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Littleton?

Yes, this clinical trial (NCT07271485) has an active research site in Littleton, CO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Misophonia Treatment Options in Littleton, CO

If you're searching for misophonia treatment options in Littleton, CO, this clinical trial (NCT07271485) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Littleton research site is actively enrolling participants for this clinical trial. You'll receive care from experienced misophonia specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all misophonia clinical trials near you to find additional studies recruiting in your area.

Misophonia Clinical Trial in Littleton, CO

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