NCT05947279 · Virginia Commonwealth University
Examining Lateralized Aspects of Motor Control Using Non-invasive Neural Stimulation
What this study is about
Motor adaptation and generalization are believed to occur via the integration of various forms of sensory feedback for a congruent representation of the body's position in space along with estimation of inertial properties of the limb segments for accurate specification of movement.
View original scientific description
Motor adaptation and generalization are believed to occur via the integration of various forms of sensory feedback for a congruent representation of the body's position in space along with estimation of inertial properties of the limb segments for accurate specification of movement. Thus, motor adaptation is often studied within curated environments incorporating a "mis-match" between different sensory systems (i.e. a visual field shift via prism googles or a visuomotor rotation via virtual reality environment) and observing how motor plans change based on this mis-match. However, these adaptations are environment-specific and show little generalization outside of their restricted experimental setup. There remains a need for motor adaptation research that demonstrates motor learning that generalizes to other environments and movement types. This work could then inform physical and occupational therapy neurorehabilitation interventions targeted at addressing motor deficits.
Interventions
BEHAVIORAL
Comparing motor adaptation reaching performance
By comparing motor adaptation reaching performance between these three groups, the investigators can examine how stimulation to each specific area of the brain modulates different aspects of motor adaptation
Primary outcome measures
Initial direction error, or difference between participant's fingertip direction
Time frame: Completion of the study visit, approx 20 minutes
Initial direction error, or difference between participant's fingertip direction at the timepoint of peak velocity relative to a linear path to the target. As for time frame, this is a single-visit study. Initial direction error will be compared during baseline reaching and following 20 minutes of non-invasive neural stimulation.
Initial direction error variance
Time frame: Completion of the study visit, approx 20 minutes
Initial direction error variance across multiple trials.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Right-handed as determined by the short-form Edinburgh Handedness Inventory
- Between the ages of 18 and 40
Exclusion criteria
- Mixed- or left-handed as determined by the short-form Edinburgh Handedness Inventory
- Self-reported history of any of the following: Seizure and/or diagnosis of epilepsy Fainting spells Concussion with loss of consciousness Ringing in the ears (tinnitus) Cochlear implants Migraines Diagnosed psychological or neurological condition Metal in the scalp
- Any previous adverse reaction to a brain stimulation technique
- Any previous adverse reaction to 3D virtual reality environments (i.e. 'cybersickness')
- Possibility of being currently pregnant (for females only)
- Current open head wound or skin condition of the scalp
- Current implanted device(s) (i.e. cardiac pacemaker)
Where
- Richmond, Virginia
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
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How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 13, 2026 · Source of record for eligibility and locations