Lexington, KYNCT06683365Now EnrollingIRB Ready

Multiple System Atrophy Clinical Trial in Lexington, KY

Access cutting-edge multiple system atrophy treatment through this clinical trial at a research site in Lexington. Study-provided care at no cost to qualified participants.

Sponsored by Craig van Horne, MD, PhD

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Expert Care in Lexington

Access multiple system atrophy specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related multiple system atrophy treatment provided free

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Check if you qualify for this multiple system atrophy clinical trial in Lexington, KY

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Lexington

    Convenient for KY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Lexington site if eligible
  4. 4Begin participation

About This Multiple System Atrophy Study in Lexington

This phase I double-blind study focuses on the safety and feasibility of implanting autologous peripheral nerve tissue (PNT) into the substantia nigra area of the brain in persons who have been diagnosed with either Parkinson's disease (PD) or Multiple System Atrophy (MSA). 7 participants will be enrolled, with 4 participants receiving the graft and 3 receiving a sham surgery. Eligible participants will be early in their diagnosis with a lower burden of symptoms. Participants will be followed initially for one year after surgery.

Sponsor: Craig van Horne, MD, PhD

Who Can Participate

Inclusion Criteria

Diagnosis of clinically established or clinically probable PD or MSA as defined by MDS criteria
Disease duration greater than 2 years
Age 40-75, inclusive
MDS-Unified Parkinson's Disease Rating Scale (UPDRS) Part III greater than or equal to 20 points but less than or equal to 35 points, off anti-parkinsonian medication for PD or MDS-Unified Multiple System Atrophy Rating Scale (UMSARS) less than or equal to 30 points off anti-parkinsonian medication
No MDS-UPDRS Part III score \>3 on items 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.14 while off medication
Able and willing to undergo ioflupane/SPECT
Able to tolerate the surgical procedure
Able to undergo all planned assessments
Available access to the sural nerve

Exclusion Criteria

Previous PD surgery or intracranial surgery
Ongoing major medical or psychiatric disorder incl. depression and psychosis
Other concomitant treatment with neuroleptics
Typical, nonparkinsonian syndrome ioflupane/SPECT signal
Unable to undergo an MRI
An obstructed trajectory path to the substantia nigra
Significant microvascular disease
Use of anticoagulants other than aspirin
Female who is pregnant, lactating, or of child-bearing potential unwilling to use an adequate birth control method during the period of the study
Consent capacity will be assessed and determined during and throughout a participant's neuropsychological exam. A participant who experiences a decline in consent capacity prior to surgery, will be removed from the study by the PI. A decline in consent capacity after surgery will not result in the removal of the participant in the study.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Lexington?

Yes, this clinical trial (NCT06683365) has an active research site in Lexington, KY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Multiple System Atrophy Treatment Options in Lexington, KY

If you're searching for multiple system atrophy treatment options in Lexington, KY, this clinical trial (NCT06683365) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Lexington research site is actively enrolling participants for this clinical trial. You'll receive care from experienced multiple system atrophy specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all multiple system atrophy clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Lexington, KY