Salt Lake City, UTNCT06185179Now EnrollingIRB Ready

Muscle Atrophy or Weakness Clinical Trial in Salt Lake City, UT

Access cutting-edge muscle atrophy or weakness treatment through this early phase 1 clinical trial at a research site in Salt Lake City. Study-provided care at no cost to qualified participants.

Sponsored by University of Utah

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Expert Care in Salt Lake City

Access muscle atrophy or weakness specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related muscle atrophy or weakness treatment provided free

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Check if you qualify for this muscle atrophy or weakness clinical trial in Salt Lake City, UT

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Salt Lake City

    Convenient for UT residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Salt Lake City site if eligible
  4. 4Begin participation

About This Muscle Atrophy or Weakness Study in Salt Lake City

A hallmark of aging is an impaired ability to adequately recover following a stressor, such as muscle disuse, resulting in muscle fibrosis and weakness thereby increasing the risk for falls and loss of independence. Mechanistic-based therapeutic strategies to enhance muscle recovery in older adults do not exist. Metformin has been implicated to have positive effects on muscle size and function through non-glycemic mechanisms. Metformin has been shown to enhance macrophage function and lessen cellular senescence burden by targeting SASP in a variety of muscle interstitial cells. However, the role of metformin to improve muscle recovery in older adults following disuse atrophy through immunomodulating and senomorphic mechanisms have not been examined. Therefore, the purpose of this study is to conduct a randomized, double blind, placebo-controlled clinical trial in older adult participants to determine if short-term metformin delivery (vs placebo) during the recovery phase following disuse atrophy can improve muscle regrowth.

Sponsor: University of Utah

Who Can Participate

Inclusion Criteria

Age between 60y and older
BMI: \<30 kg/m2
Good general medical health, ambulatory and in independent living setting
Adequate upper body strength to use assistive walking device (crutches, walker, etc) as assessed by PI/staff during screening
Clinical Frailty Scale score \< 3
Mini-Cog score \> 3

Exclusion Criteria

History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)
History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted)
History of kidney disease or failure (CKD \> stage 4; serum creatinine \>1.5mg/dL)
History of vascular disease
Risk of DVT including family history of thrombophilia, DVT, pulmonary emboli, myeloproliferative diseases including polycythemia (Hb\>18 g/dL) or thrombocytosis (platelets\>400x103/mL), and connective tissue diseases (positive lupus anticoagulant), hyperhomocystinemia, deficiencies of factor V Leiden, proteins S and C, and antithrombine III
Use of anticoagulant therapy (e.g., Coumadin, heparin)
Uncontrolled hypertension - Elevated systolic pressure \>150 or a diastolic blood pressure \> 100
Implanted electronic devices (e.g., pacemakers, electronic infusion pumps, stimulators)
Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted)
Androgens or growth hormone within 6 months of enrollment and for study duration (topical physiologic androgen replacement will be permitted)
Inability to abstain from smoking or vaping for duration of study
Currently taking estrogen products (topical estrogen products will be permitted)
Currently on weight loss diet or medication
History of stroke with motor disability
A recent history (\<12 months) of GI bleed
History of liver disease or AST/ALT 2 times above the normal limit
History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
Any staff members who report directly to the principal investigators

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Salt Lake City?

Yes, this clinical trial (NCT06185179) has an active research site in Salt Lake City, UT that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Muscle Atrophy or Weakness Treatment Options in Salt Lake City, UT

If you're searching for muscle atrophy or weakness treatment options in Salt Lake City, UT, this clinical trial (NCT06185179) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Salt Lake City research site is actively enrolling participants for this early phase 1 clinical trial. You'll receive care from experienced muscle atrophy or weakness specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all muscle atrophy or weakness clinical trials near you to find additional studies recruiting in your area.

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