NCT07166198 · Kansas State University
Mitigating Neural Hypoexcitability and Weakness During Disuse in Women
(MiND)
What this study is about
Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of treatment group$1 immobilization and whether a type of exercise called cross-education can help reduce these effects in women at midlife.
View original scientific description
Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in women at midlife. The main questions it aims to answer are: What changes happen in the nervous system that lead to weakness when a wrist is immobilized? Can training the opposite arm help maintain muscle strength, muscle size, and nervous system function in the immobilized arm? Researchers will compare women who have their wrist immobilized with or without opposite-arm resistance training.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Women between 40-65 years of age
- Baseline handgrip strength \>16Kg
Exclusion criteria
- Personal or family history of blood clots
- Current use of anticoagulant medications
- Neuromuscular or metabolic diseases (e.g., multiple sclerosis, diabetes)
- Osteoporosis or osteopenia
- History of myocardial infarction within the past year
- Chronic pain ≥3/10 for ≥3 months
- Uncontrolled hypertension (≥140/90 mmHg)
- Upper extremity surgery within the past year
- Use of assistive hand or arm device within the past year
- Fall involving the upper extremities within the past year
- Upper extremity injuries preventing safe participation
- Current use of muscle relaxants, benzodiazepines, or similar drugs
- Smoking within the past 6 months
- History of drug or alcohol abuse within the past year
- Severe anxiety or claustrophobia
- Pregnancy (current or planned)
- Allergies to medical adhesives
- High risk of sarcopenia (per SARC-F)
- Contraindications to TMS or MRI
- Upper-body resistance training within the past 6 months
- Inability/unwillingness to refrain from resistance training during study
Where
- Manhattan, Kansas
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 10, 2026 · Source of record for eligibility and locations