Pasadena, CANCT07647510Now EnrollingIRB Ready

Myasthenia Gravis, Generalized Clinical Trial in Pasadena, CA

Access cutting-edge myasthenia gravis, generalized treatment through this phase 3 clinical trial at a research site in Pasadena. Study-provided care at no cost to qualified participants.

Sponsored by Dianthus Therapeutics

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Expert Care in Pasadena

Access myasthenia gravis, generalized specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related myasthenia gravis, generalized treatment provided free

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Check if you qualify for this myasthenia gravis, generalized clinical trial in Pasadena, CA

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Why Participate?

  • No-Cost Study Care

  • Local to Pasadena

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Pasadena site if eligible
  4. 4Begin participation

About This Myasthenia Gravis, Generalized Study in Pasadena

The purpose of this Phase 3 study is to demonstrate the efficacy, safety, and tolerability of claseprubart in participants with generalized myasthenia gravis (gMG).

Sponsor: Dianthus Therapeutics

Who Can Participate

Inclusion Criteria

Must have given written informed consent before any study-related activities are carried out
Weight range between 40-130 kg at Screening
Diagnosis of gMG by the following tests:
Acetylcholine receptor antibody (AChR Ab) positive, and
One of the following: i. History of abnormal neuromuscular transmission test; ii. History of positive anticholinesterase test; iii. Clinical response to acetylcholinesterase inhibitors.
Myasthenia Gravis Foundation of America (MGFA) Class II-IVa
MG-ADL scale score of 6 or more
QMG scale score of 10 or more
Documented vaccinations against encapsulated bacteria in accordance with local requirements and based on vaccine availability
Female participants must be of non-childbearing potential, or if of childbearing potential, must agree not to donate ova, not to attempt to become pregnant and, if engaging in sexual intercourse with a male partner, must agree to use a highly effective method of contraception
Male participants agree not to donate sperm and, if engaging in sexual intercourse with a female partner who could become pregnant, must agree to use an acceptable method of contraception

Exclusion Criteria

History or presence of significant medical/surgical condition including any acute illness, mental illness, or major surgery considered to be clinically significant or that could have potential impact on safety/efficacy or study procedures
Known complement deficiency
Prior history (at any time) of N. meningitidis infection
Participants with known seropositivity or who test positive for an active viral infection with human immunodeficiency virus (HIV-1 or HIV-2), hepatitis B (HBV; except participants who are seropositive because of HBV vaccination) or hepatitis C virus (HCV) during Screening
Previous treatment with claseprubart (DNTH103) or participation in a clinical trial with claseprubart. \[
Any thymic surgery/biopsy within 1 year of Screening
Any known or untreated thymoma.
Any history of thymic carcinoma or thymic malignancy
History of active malignancy within 5 years prior to Screening, except basal cell carcinoma of the skin, curatively resected squamous cell carcinoma of the skin, cervical carcinoma in situ curatively treated or low-grade prostate adenocarcinoma for which appropriate management is observation alone
Concurrent or previous use of the following medication within the time periods specified below.
Rituximab or other B-cell targeting therapies (ie, inebilizumab) within 6 months (180 days) prior to randomization (Day 1);
Intravenous immunoglobulin (IVIg) and plasma exchange (PLEX) within 4 weeks (28 days) prior to randomization (Day 1)
Participation in another clinical study of an investigational drug within 90 days or 5 half-lives of the investigational agent
Diagnosis of systemic lupus erythematosus (SLE) or family history (defined as a parent, sibling, or child) of SLE

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Pasadena?

Yes, this clinical trial (NCT07647510) has an active research site in Pasadena, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Myasthenia Gravis, Generalized Treatment Options in Pasadena, CA

If you're searching for myasthenia gravis, generalized treatment options in Pasadena, CA, this clinical trial (NCT07647510) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Pasadena research site is actively enrolling participants for this phase 3 clinical trial. You'll receive care from experienced myasthenia gravis, generalized specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all myasthenia gravis, generalized clinical trials near you to find additional studies recruiting in your area.

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