NCT06866483 · ZS Associates
Validation and Scaling of Screening Program for Undiagnosed Myasthenia Gravis-Social Media Campaign Paired With a Self-moderated Assessment
What this study is about
This study expands and validates the pilot study NCT06381284. It is a fully remote, site-less, forward-looking, observational study enrolling adults in the United States (excluding U.S. territories) with undiagnosed neuromuscular symptoms.
View original scientific description
This study expands and validates the pilot study NCT06381284. It is a fully remote, site-less, prospective, observational study enrolling adults in the United States (excluding U.S. territories) with undiagnosed neuromuscular symptoms. The primary objective is to determine the validity of a self-assessment tool in encouraging undiagnosed participants, recruited through a social media campaign, to seek medical evaluation for suspected myasthenia gravis (MG).
Interventions
BEHAVIORAL
Social media recruitment
Social media users exposed to a variety of paid social media advertisements as a recruitment tool for study enrollment
BEHAVIORAL
Self-Assessment
Eligible participants are asked to complete self-administered physical tests to assess inducible fatigue of specific muscle groups
BEHAVIORAL
Follow-up
Patients triaged based on their assessed risk of MG are asked to complete recommended follow-up with a clinician to determine presence of myasthenia gravis
Primary outcome measures
Self-Assessment tool validity
Time frame: 6 months from time of enrollment
Measure the specificity and sensitivity of the Self-Assessment tool
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Reside within the 50 states of the United States at the time of enrollment
- Age 19 or older if reside in Nebraska or Alabama, Age 21 or older if reside in Mississippi, Age 18 years or older if reside in any other state
- Active email account
- Fluency in English (spoken / written), as demonstrated by the ability to read and sign the Informed Consent Form
Exclusion criteria
- Live in an overseas territory of the United States
- Inability or unwillingness to provide written informed consent
- Diagnosed myasthenia gravis, including sero-negative MG\
- Diagnosed multiple sclerosis
- Have speech impairment, eye/arm/leg weakness due to diagnosed brain cancer, or stroke
Where
- Evanston, Illinois
Collaborators
UCB Pharma, University of California, San Francisco
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 10, 2025 · Source of record for eligibility and locations