NCT06491238 · HealthPartners Institute
Light vs. Moderate Intensity Exercise in Individuals With Myasthenia Gravis
(MG-Ex)
What this study is about
The overall purpose of this pilot study is to examine the feasibility, acceptability, and tolerability of light and moderate intensity exercise in adults with MGeffect of light vs. moderate intensity exercise on health outcomes.
View original scientific description
The overall purpose of this pilot study is to examine the feasibility, acceptability, and tolerability of light and moderate intensity exercise in adults with MGeffect of light vs. moderate intensity exercise on health outcomes. Participants will be enrolled into the NeuroWell exercise program, which is geared toward individuals with neurological disorders or injuries and led by Certified Exercise Physiologists (CEPs) at the HealthPartners Neuroscience Center. A total of 20 people with MG will be enrolled in this study and participate in a small group exercise program 3 times a week for 12 weeks. Participants will be randomized into two exercise groups: 1) Light intensity or 2) Moderate intensity. We hypothesize that light and moderate intensity exercise will be feasible, acceptable, and tolerable in adults with MG and that individuals in the light intensity exercise group will be able to achieve the same improvement in health outcomes as the moderate intensity group.
Interventions
BEHAVIORAL
Light Intensity Exercise
12 weeks light intensity strength and endurance NeuroWell exercise program, specifically developed for individuals with neurological disorders or injuries. Participants have the intensity goals descripted in the experimental arm.
BEHAVIORAL
Moderate Intensity Exercise
12 weeks moderate intensity strength and endurance NeuroWell exercise program, specifically developed for individuals with neurological disorders or injuries. Participants have the intensity goals descripted in the experimental arm.
Primary outcome measures
Feasibility of light and moderate intensity exercise
Time frame: 12 weeks
Percent of participants recruited of potential participants contacted. Range: \[0-100\]. Higher percentage indicates higher feasibility
Acceptability of light and moderate intensity exercise
Time frame: 12 weeks
Percent of participants who complete the program of participants who start the program. Range: \[0-100\]. Higher percentage indicates higher acceptability
Tolerability of light and moderate intensity exercise
Time frame: 12 weeks
Percent of classes participants complete during the course of the program. Range: \[0-100\]. Higher percentage indicates higher tolerability.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Ability to provide and provision of signed and dated informed consent form.
- Diagnosis of generalized MG.
- On a stable MG prescription medication regimen for the last 3 months.
Exclusion criteria
- Non-English speaking
- Regular exercise participation within the month prior to study enrollment or any outside exercise participation during the study intervention period.
- Significant cognitive impairment of any etiology that would impact study participation.
- History of heart failure, chronic lung disease, angina or any other condition that causes unreasonable shortness of breath on exertion.
- History of any serious neurological, psychiatric, or substance use disorders that would impact study participation.
- Women who are currently pregnant or planning to become pregnant during the study.
- Any other medical conditions that could affect their ability to participate in exercise for the study duration (as determined by study investigators).
- Active participation or past participation ≤3 months in any other interventional research study.
- Unwilling to participate in all study related activities.
Where
- Saint Paul, Minnesota
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 23, 2026 · Source of record for eligibility and locations