Birmingham, ALNCT04227847Now EnrollingIRB Ready

Myelodysplastic Syndrome Clinical Trial in Birmingham, AL

Access cutting-edge myelodysplastic syndrome treatment through this clinical trial at a research site in Birmingham. Study-provided care at no cost to qualified participants.

Sponsored by Seagen, a wholly owned subsidiary of Pfizer

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Expert Care in Birmingham

Access myelodysplastic syndrome specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related myelodysplastic syndrome treatment provided free

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Check if you qualify for this myelodysplastic syndrome clinical trial in Birmingham, AL

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Why Participate?

  • No-Cost Study Care

  • Local to Birmingham

    Convenient for AL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Birmingham site if eligible
  4. 4Begin participation

About This Myelodysplastic Syndrome Study in Birmingham

This trial will look at a drug called SEA-CD70 with and without azacitidine, to find out if it is safe for participants with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It will study SEA-CD70 to find out what its side effects are and if it works for AML and MDS. A side effect is anything the drug does besides treating cancer. This study will have seven groups or "parts." * Part A will find out how much SEA-CD70 should be given to participants * Part B will use the dose found in Part A to find out how safe SEA-CD70 is and if it works to treat participants with MDS. * Part C will use the dose found in Part A to find out how safe SEA-CD70 is and if it works to treat participants with AML. * Part D will find out how much SEA-CD70 with azacitidine should be given to participants * Part E will use the dose found in Part D to find out how safe SEA-CD70 with azacitidine is and if it works to treat participants with MDS or MDS/AML that has not been treated. * Part F will use the dose found in Part D to find out how safe SEA-CD70 with azacitidine is and if it works to treat participants with MDS or MDS/AML. * Part G will find out how much SEA-CD70 with azacitidine and with venetoclax should be given to participants with AML. Also, to evaluate safety and tolerability of PF-08046040 in combination with azacitidine and venetoclax in participants with previously untreated AML who are unfit for standard induction chemotherapy.

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Who Can Participate

Inclusion Criteria

Participants with cytologically/histologically confirmed MDS (2016 World Health Organization (WHO) classification) with
Measurable disease per WHO MDS with excess blasts criteria
MDS that is relapsed or refractory and must not have other therapeutic options
Treatment failure after prior hypomethylating agent (HMA) therapy for MDS
Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 Part B Inclusion Criteria
Participants with cytologically/histologically confirmed MDS (WHO classification) with:
Measurable disease per WHO MDS with excess blasts (MDS-EB) criteria
MDS that is relapsed or refractory and must not have other therapeutic options
Treatment failure after prior HMA therapy for MDS
ECOG Performance Status of 0-2 Part C Inclusion Criteria
Participants with relapsed or refractory AML (ICC 2022) (except for acute promyelocytic leukemia \[APL\]):
Who have received either 2 or 3 previous regimens
Who have received 1 previous regimen to treat active disease and have at least one of the following:
Age \> 60 and ≤75 years.
Primary resistant AML or secondary AML
First CR duration \<6 months
Adverse-risk per European Leukemia Network genetic risk stratification
Age 18-75 years
ECOG performance status of 0-2 Parts D and F Inclusion Criteria
Participants with diagnosis of MDS or MDS/AML (ICC 2022 criteria)
Disease which has relapsed, failed to respond after minimum of 6 cycles, or progressed following an HMA in the immediately preceding line of therapy.
Eligible for continued therapy with azacitidine
ECOG Performance Status 0-2 Parts D and E Inclusion Criteria
Participants with diagnosis of MDS or MDS/AML (ICC 2022 criteria), previously untreated.
Participants with higher-risk per IPSS-M MDS and MDS/AML
ECOG Performance Status 0-2 Part G Inclusion Criteria
Participants with diagnosis of AML (ICC 2022 criteria), previously untreated and ineligible for standard induction chemotherapy.
Age ≥18 years.
ECOG Performance Status of 0-2.

Exclusion Criteria

(All Parts)
Previous exposure to CD70-targeted agents
Prior allogeneic hematopoietic stem cell transplant, for any condition
Central nervous system leukemia
History of clinically significant sickle cell anemia, autoimmune hemolytic anemia, or idiopathic thrombocytopenic purpura
Parts D, F and G only: Prior oral HMA or oral HMA-combinations
Part G: conditions that preclude enteral route of administration; concomitant use of strong/moderate CYP3A inducers; history of myeloproliferative neoplasm

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Birmingham?

Yes, this clinical trial (NCT04227847) has an active research site in Birmingham, AL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Myelodysplastic Syndrome Treatment Options in Birmingham, AL

If you're searching for myelodysplastic syndrome treatment options in Birmingham, AL, this clinical trial (NCT04227847) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Birmingham research site is actively enrolling participants for this clinical trial. You'll receive care from experienced myelodysplastic syndrome specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all myelodysplastic syndrome clinical trials near you to find additional studies recruiting in your area.

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See all myelodysplastic syndromes clinical trials recruiting in Birmingham — not just this study.

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