Culver City, CANCT07565428Now EnrollingIRB Ready

Negative Symptoms of Schizophrenia Clinical Trial in Culver City, CA

Access cutting-edge negative symptoms of schizophrenia treatment through this clinical trial at a research site in Culver City. Study-provided care at no cost to qualified participants.

Sponsored by Minerva Neurosciences

Quick Self-Assessment

See if you qualify for this Culver City location

Preparing your pre-screening questions…

Expert Care in Culver City

Access negative symptoms of schizophrenia specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related negative symptoms of schizophrenia treatment provided free

Apply for This Culver City Location

Check if you qualify for this negative symptoms of schizophrenia clinical trial in Culver City, CA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Culver City

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Culver City site if eligible
  4. 4Begin participation

About This Negative Symptoms of Schizophrenia Study in Culver City

Evaluate the efficacy, as well as safety and pharmacokinetics, of Roluperidone in improving the negative symptoms of schizophrenia in adult subjects in Phase A of study, followed by Phase B of study to evaluate the relapse rate of Roluperidone and antipsychotic medications.

Sponsor: Minerva Neurosciences

Who Can Participate

Inclusion Criteria

Subject and subject's legal representative, if applicable, provided informed consent prior to the initiation of any study related procedures, and the subject is judged by the investigator as being capable of understanding the study requirements.
Male or female, 18 to 55 years of age, inclusive, and body mass index (BMI) \</= 35.0 kg/m2 at Screening.
Meets the diagnostic criteria for schizophrenia as defined in the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5), as established by a full psychiatric interview in conjunction with the Mini International Neuropsychiatric Interview (MINI).
Has a caregiver or family member or health care personnel who can provide information towards assessment and support the subject in terms of compliance with the protocol. The caregiver must have contact with the subject frequently and is not expected to change during the trial.
Documented diagnosis of schizophrenia for at least 1 year before screening into the trial.
Is stable in terms of both positive and negative symptoms of schizophrenia over the last 6 months according to his or her clinician and/or based on documentation in the clinical chart or medical records, and/or based on information from a professional caregiver, when formal clinician documentation is not available. Subjects with or without positive symptoms are allowed if these symptoms are stable for the last 6 months and the subjects do not meet

Exclusion Criteria

criterion 2.
Is currently an outpatient and has not been hospitalized for the last 6 months for acute exacerbation or symptoms worsening.
Has had a stable living condition (residence) for the last 6 months.
Has not been hospitalized within 6 months before Screening. A subject hospitalized for any time period during the last 6 months for social reasons or currently hospitalized for reasons not related to their schizophrenia illness (e.g., has no support system in the community or needs to have eligibility for disability support periodically re-assessed) can be included only with sponsor/CRO's medical monitors approval and after considering the applicable local regulation requirements. The social reasons for admission or residing in a hospital must be documented in the source documents and the electronic case report form (eCRF).
Has a score of \> 20 on the PANSS negative subscale score (\[sum of N1+N2+N3+N4+N5+N6+N7\]) at Screening (Visit 1) and Baseline (Visit 3) AND \< 4 points absolute difference between Visits 1 and 3.
Must discontinue any psychotropic medications by or at the beginning of the washout phase (Day -2). The rate of washout/discontinuation of psychotropic medications during the Screening period should be gradual in order to reduce the risk of psychotropic withdrawal symptoms but remains at the discretion of the investigator.
Has no history of violence against self or others.
Female subject, if not of childbearing potential, defined as a woman who is post-menopausal or permanently sterilized (e.g., tubal occlusion, hysterectomy, bilateral salpingectomy).
Female subject, if of childbearing potential, must test negative for pregnancy and must use 2 approved methods of highly effective contraception.
Must be normal or ultrarapid metabolizer for cytochrome P450 (CYP) 2D6, defined as having an activity score (AS) of \>/= 1.25 as determined by study-specific genotyping test before the first dose of study drug dose is administered.
Subject and the caregiver are considered by the investigator to be reliable and likely to cooperate with the assessment procedures. Exclusion Criteria:
Current major depressive disorder, bipolar disorder, panic disorder, obsessive compulsive disorder, or intellectual disability (intellectual developmental disorder diagnosed by age 14), drugs or alcohol addiction.
PANSS item score of \> 4 on any of the following items: P4 Excitement/Hyperactivity; P6 Suspiciousness/persecution; P7 Hostility; G8 Uncooperativeness; G14 Poor impulse control.
A Calgary Depression Scale for Schizophrenia (CDSS) total score \> 6.
A score of \>/= 2 on any 2 items of items 1, 2, or 3, or a score of \>/= 3 on item 4 of the Barnes Akathisia Rating Scale (BARS).
Subject's condition is due to direct physiological effects of a substance (e.g., a drug of abuse, or medication) or a general medical condition.
Current or recent history of serious suicidal behavior within the past 1 year.
History of substance use disorder within 3 months of the Screening visit (excluding caffeine and cigarette smoking).
Positive urine drug screen for any drug of abuse (cocaine, methadone, amphetamines, cannabinoids, opiates, benzodiazepines, and barbiturates), tricyclic antidepressants (TCA), and alcohol (except for prescription benzodiazepines).
Cannot be discontinued from psychotropics.
Received clozapine within 6 months of the Screening visit except when used for insomnia at doses \</= 100 mg per day.
Was treated with electroconvulsive therapy or transcranial magnetic stimulation in the last 12 months.
Is receiving treatment with long-acting or depot antipsychotic medication unless the drug has been discontinued for a full cycle drug (1 months, 3 months, 6 months depending on the drug formulation) to allow for sufficient washout before receiving the study drug.
History of significant renal disorder, including an eGFR \< 60 mL/min at the Screening visit.
History of significant other major or unstable neurological, neurosurgical (e.g., head trauma), metabolic, hepatic, hematological, pulmonary, cardiovascular, metabolic, gastrointestinal, or urological disorder.
History of seizures (subjects with a history of a single childhood febrile seizure may be enrolled in this study).
Clinically significant abnormalities in hematology, blood chemistry (including ALT or AST \> 3 × the upper limit of normal \[ULN\], total bilirubin \> 2 × ULN, or alkaline phosphatase \> 1.5 × ULN), or physical examination not resolved by the Baseline visit which according to Investigator can interfere with study participation.
Safety laboratory results from the Pretreatment Phase show one or more of the following: potassium \< 3.4 mmol/L, calcium \< 2.07 mmol/L, or magnesium \< 0.70 mmol/L.
Current systemic infection (e.g., Hepatitis B, Hepatitis C, human immunodeficiency virus \[HIV\], tuberculosis). A subject with positive Hepatitis B core antibody test and negative Hepatitis B Surface Antigen (HBsAg) may be included in the study if aminotransferase levels (alanine aminotransferases/ serum glutamate pyruvate transaminase \[ALT/SGPT\] and aspartate aminotransferase/ serum glutamic oxaloacetic transaminase \[AST/SGOT\]) do not exceed 2 × ULN.
Requires or may require concomitant treatment with any other medication likely to increase QT interval (e.g., paroxetine, fluoxetine, duloxetine, amiodarone).
Requires medication inhibiting CYP2D6.
Clinically significant ECG abnormality that could be a safety issue in the study, including QT interval value corrected for heart rate using the Fridericia's formula (QTcF) \> 430 msec for males and \> 450 msec for females.
Familial or personal history of long QT syndrome or with another risk factor for Torsade de Pointes.
History of myocardial infarction based on medical history or ECG findings at Screening.
Woman of child-bearing potential, or man, who is unwilling or unable to use accepted methods of birth control.
Woman with a positive pregnancy test, is lactating, or is planning to become pregnant during the study.
Participated in another clinical study that was completed within 6 months prior to Screening or has previously participated in \> 2 clinical studies with experimental medication within the past 2 years.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Culver City?

Yes, this clinical trial (NCT07565428) has an active research site in Culver City, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Negative Symptoms of Schizophrenia Treatment Options in Culver City, CA

If you're searching for negative symptoms of schizophrenia treatment options in Culver City, CA, this clinical trial (NCT07565428) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Culver City research site is actively enrolling participants for this clinical trial. You'll receive care from experienced negative symptoms of schizophrenia specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all negative symptoms of schizophrenia clinical trials near you to find additional studies recruiting in your area.

More Multiple Sclerosis Trials in Culver City, CA

See all multiple sclerosis clinical trials recruiting in Culver City — not just this study.

Browse Multiple Sclerosis Trials in Culver City →

Browse More Trials by Condition

Multiple Sclerosis TrialsSchizophrenia TrialsPulmonary Hypertension TrialsGeographic Atrophy TrialsAll Conditions →

Ready to Join in Culver City?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Culver City, CA