Canton, OHNCT07213609Now EnrollingIRB Ready

Neoplasms, Colorectal Clinical Trial in Canton, OH

Access cutting-edge neoplasms, colorectal treatment through this clinical trial at a research site in Canton. Study-provided care at no cost to qualified participants.

Sponsored by GlaxoSmithKline

Quick Self-Assessment

See if you qualify for this Canton location

Preparing your pre-screening questions…

Expert Care in Canton

Access neoplasms, colorectal specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related neoplasms, colorectal treatment provided free

Apply for This Canton Location

Check if you qualify for this neoplasms, colorectal clinical trial in Canton, OH

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Canton

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Canton site if eligible
  4. 4Begin participation

About This Neoplasms, Colorectal Study in Canton

Solid tumours are abnormal lumps of tissue that can occur in different parts of the body. The tumours involved in this study have specific genetic characteristics that can make them more aggressive and challenging to treat. The study will test whether GSK5460025 alone or in combination (potential combinations may be included in future amendments to the protocol) with other anti-cancer agents can decrease tumor size, is safe, well-tolerated, and how the drug is processed in the body over time.

Sponsor: GlaxoSmithKline

Who Can Participate

Inclusion Criteria

Has a histologically diagnosed advanced (unresectable, metastatic or recurrent) solid tumor
Has a known dMMR/MSI-H status as determined by a certified local laboratory at the time of Pre-screening or has an unknown Mismatch repair (MMR)/ Microsatellite Instability (MSI) status at the time of Pre-screening and MMR/MSI status will be determined by central reference laboratory
Provides an archival or fresh (preferred) formalin fixed, paraffin embedded (FFPE) sample
Intends to receive GSK5460025 as next treatment
Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
Is expected to have a minimum of 3 months life expectancy
Has adequate organ function, as defined in the protocol Part 1 inclusion criteria: • Has histologically diagnosed advanced (unresectable, metastatic or recurrent) solid tumor and has exhausted all standard of care treatment options Part 2 inclusion criteria:
Has histologically diagnosed advanced (unresectable, metastatic or recurrent) Colorectal cancer (CRC) or Endometrial cancer (EC)
Has received at least 1 but no more than 3 lines of systemic anticancer therapy for their advanced (unresectable, metastatic or recurrent) disease including at least one line of Immune checkpoint inhibitors (ICI) therapy
Has measurable disease (i.e., at least 1 target lesion) during the Screening period per RECIST 1.1, as determined by the investigator

Exclusion Criteria

Has not recovered (i.e., to Grade ≤1 or to baseline) from prior anticancer therapy-induced Adverse Events (AEs)
Has received prior treatment with a Werner (WRN) inhibitor or Nucleotide Excision Repair Targeting (NERT) agent.
Is unable to swallow and retain orally administered study treatment
Has untreated or progressed metastases in brain or CNS
Has a known additional malignancy that progressed or required active treatment within the last 2 years because reoccurrence of another malignancy would confound interpretation by RECIST 1.1 criteria. Exceptions include basal or squamous cell carcinomas of the skin or in situ carcinomas \[e.g., breast, cervix, bladder\] that have been resected with no evidence of metastatic disease.
Has any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study drugs
Has cirrhosis or current unstable liver or biliary disease
Has known hypersensitivity to any of the study interventions or any of their excipients

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Canton?

Yes, this clinical trial (NCT07213609) has an active research site in Canton, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Neoplasms, Colorectal Treatment Options in Canton, OH

If you're searching for neoplasms, colorectal treatment options in Canton, OH, this clinical trial (NCT07213609) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Canton research site is actively enrolling participants for this clinical trial. You'll receive care from experienced neoplasms, colorectal specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all neoplasms, colorectal clinical trials near you to find additional studies recruiting in your area.

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