New Hyde Park, NYNCT05588063Now EnrollingIRB Ready

Nephrotic Syndrome in Children Clinical Trial in New Hyde Park, NY

Access cutting-edge nephrotic syndrome in children treatment through this clinical trial at a research site in New Hyde Park. Study-provided care at no cost to qualified participants.

Sponsored by Northwell Health

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Expert Care in New Hyde Park

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related nephrotic syndrome in children treatment provided free

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Check if you qualify for this nephrotic syndrome in children clinical trial in New Hyde Park, NY

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Why Participate?

  • No-Cost Study Care

  • Local to New Hyde Park

    Convenient for NY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit New Hyde Park site if eligible
  4. 4Begin participation

About This Nephrotic Syndrome in Children Study in New Hyde Park

Children with frequently relapsing nephrotic syndrome (FRNS) are exposed to prolonged courses of steroids and other immunosuppressant medications. Given the adverse side effect profiles and variable efficacy of these medications, there is an urgent need to identify novel and safe therapies to treat nephrotic syndrome in children. Stimulation of the vagus nerve, which can be activated non invasively by transcutaneous auricular vagus nerve stimulation (taVNS), has immunomodulatory effects mediated by the inflammatory reflex and spleen. taVNS has become a therapy of interest for treating chronic immune mediated illnesses. The aims of the study are (1) To determine the feasibility of protocol implementation and tolerability of taVNS in the treatment of nephrotic syndrome in children (2) To establish proof-of-concept and generate statistical estimates of variance parameters and effect sizes for treatment response outcomes in children with nephrotic syndrome randomized to taVNS therapy compared with sham therapy (3) To investigate the effects of taVNS on inflammatory markers in children with nephrotic syndrome.

Sponsor: Northwell Health

Who Can Participate

Inclusion Criteria

Age 3-17 years
Glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2
Minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS) diagnosis (clinical diagnosis or per biopsy)
Steroid sensitive nephrotic syndrome (prior history of remission within 4 weeks of steroid therapy)
In remission at time of enrollment (remission defined as UPC \<0.2 or negative dipstick for 3 consecutive days)
Informed consent from the parent or guardian and assent from a minor of ≥ 7. years

Exclusion Criteria

Secondary forms of nephrotic syndrome
Steroid dependent nephrotic syndrome (relapse within 14 days of stopping steroids or relapse while on steroids)
Exposure to steroids within 14 days of enrollment
Receiving any standing immunosuppression (previous exposure \> 2 months allowed and/or B cell repletion)
Any known inflammatory condition (e.g. systemic lupus erythematosis)
History of cardiac disease (arrhythmias, structural/functional abnormalities)
Implantable electronic devices
Participants/guardians or participants who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New Hyde Park?

Yes, this clinical trial (NCT05588063) has an active research site in New Hyde Park, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Nephrotic Syndrome in Children Treatment Options in New Hyde Park, NY

If you're searching for nephrotic syndrome in children treatment options in New Hyde Park, NY, this clinical trial (NCT05588063) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New Hyde Park research site is actively enrolling participants for this clinical trial. You'll receive care from experienced nephrotic syndrome in children specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all nephrotic syndrome in children clinical trials near you to find additional studies recruiting in your area.

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