Denver, CONCT07735637Now EnrollingIRB Ready

Newly Diagnosed Multiple Myeloma (NDMM) Clinical Trial in Denver, CO

Access cutting-edge newly diagnosed multiple myeloma (ndmm) treatment through this phase 3 clinical trial at a research site in Denver. Study-provided care at no cost to qualified participants.

Sponsored by AstraZeneca

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Expert Care in Denver

Access newly diagnosed multiple myeloma (ndmm) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related newly diagnosed multiple myeloma (ndmm) treatment provided free

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Check if you qualify for this newly diagnosed multiple myeloma (ndmm) clinical trial in Denver, CO

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Denver

    Convenient for CO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Denver site if eligible
  4. 4Begin participation

About This Newly Diagnosed Multiple Myeloma (NDMM) Study in Denver

The purpose of this study is to measure the efficacy of AZD0120 compared with ASCT in terms of progression-free survival (PFS) according to the International Myeloma Working Group (IMWG) criteria 2016, and MRD negative complete response (CR) rate at 9 months as assessed by Blinded Independent Central Review (BICR), in participants with TE NDMM. Study details include: * The study duration is estimated to be up to 13 years from the date the first participant is randomised. * For participants in Arm A (AZD0120), the total duration of participant follow-up will be 15 years (including a Long Term Follow-up study) after the last participant has received the AZD0120 infusion. * The treatment duration will be:- Arm A (AZD0120): lymphodepletion over 3 days, a single-day infusion of AZD0120, followed by a maximum of 2 years lenalidomide monotherapy maintenance treatment. * Arm B (ASCT): conditioning therapy over 24 to 48 hours, ASCT, followed by a maximum of 2 years lenalidomide monotherapy maintenance treatment. Disclosure Statement: This is an open-label, randomised study with 2 treatment arms.

Sponsor: AstraZeneca

Who Can Participate

Inclusion Criteria

≥18 years of age.
Documented diagnosis of NDMM according to IMWG diagnostic criteria.
Documented measurable disease at diagnosis (serum M-protein ≥ 1.0 g/dL, urine M-protein 200 mg/24 hour, or serum Ig FLC 10 mg/dL (100 mg/L) and abnormal serum Ig kappa lambda FLC ratio)
Must have completed 4 to 6 cycles of induction therapy with any of the following approved regimens: anti-CD38+VRd, DVTd, DRd or VRd
Participant must have at least SD or better per IMWG response criteria (2016) after completion of induction, and prior to randomisation.
ECOG performance status score of 0 or 1.
Eligible for treatment with high-dose melphalan (200 mg/m²) followed by ASCT.
Adequate organ and bone marrow function.

Exclusion Criteria

Known active, or prior history of CNS involvement or exhibits clinical signs of meningeal involvement of MM.
Primary amyloidosis, active plasma cell leukaemia (at diagnosis and/or at time of screening), Waldenstrom macroglobulinemia or POEMS syndrome.
Significant neurological or psychiatric condition
Significant medical condition that places the participant at an unacceptable risk for treatment-related complications
Participants who required the introduction of an additional agent therapy due to inadequate response.
Prior T-cell engager therapy directed at any target.
Prior CAR-T and/or CAR-NK cell therapy directed at any target for any indications
Prior any therapy that is targeted to BCMA and CD19.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Denver?

Yes, this clinical trial (NCT07735637) has an active research site in Denver, CO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Newly Diagnosed Multiple Myeloma (NDMM) Treatment Options in Denver, CO

If you're searching for newly diagnosed multiple myeloma (ndmm) treatment options in Denver, CO, this clinical trial (NCT07735637) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Denver research site is actively enrolling participants for this phase 3 clinical trial. You'll receive care from experienced newly diagnosed multiple myeloma (ndmm) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all newly diagnosed multiple myeloma (ndmm) clinical trials near you to find additional studies recruiting in your area.

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