Is NCT07283822 recruiting in New York, NY?

Yes, NCT07283822 is currently recruiting participants at its New York, NY location. This non-hodgkin lymphoma clinical trial is actively enrolling qualified participants.

How do I join the non-hodgkin lymphoma clinical trial in New York?

To join this clinical trial in New York, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this New York clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Non-Hodgkin Lymphoma Clinical Trial in New York, NY

Who Can Participate

Inclusion Criteria

(1) Histologically confirmed relapsed/refractory HL, PMBCL, GZL, and TCL including the below subtypes:

Arm 1: PTCL

Nodal PTCL Peripheral T-cell Lymphoma- Not Otherwise Specified (PTCL-NOS)

Anaplastic Large Cell Lymphoma (ALCL) T-follicular Helper Lymphomas (TFH) and its subtypes including angioimmunoblastic T-cell Lymphoma (AITL)

Extranodal NK/T-cell lymphoma

Subcutaneous Panniculitis T-Cell Lymphoma

Arm 2: CTCL

Mycosis Fungoides

Sezary Syndrome

Arm 3: exploratory cohort

(2) All patients must have received at least one-line systemic therapy.

Patients with systemic ALCL must have received prior CD30-directed therapy.

Other PTCL subtypes that express CD30 (\>10%), must have received prior CD30-directed therapy.

Special Consideration for CTCL in Arm 2:

Systemic therapies including bexarotene (targretin) are permissible up to 2 weeks prior to enrollment.

Skin directed therapies including light therapy/phototherapy, extracorporeal photopheresis (ECP), topical steroids, or mechlorethamine (valchlor) gel are NOT considered a systemic line of therapy when given alone.

Treatment with radiation, phototherapy, histone deacetylase inhibitor, retinoids, interferons, therapeutic doses of systemic corticosteroids, or denileukin diftitox (18 µg/kg/day) up to 2 weeks prior to enrollment is allowed.

Treatment with alemutuzumab up to 8 weeks prior to enrollment is permissible.

(3) Patients must not have had chemotherapy or immunotherapy within 2 weeks prior to entering the study and must have recovered from adverse events (to grade 1 or less)

(4) Anti PD-1/PDL-1is permissible up to two weeks prior to enrollment.

(5) Age ≥ 18

(6) Participants must have measurable disease, as defined in the protocol

Patients must have a PET-CT scan performed within ≤4 weeks.

Contrast enhanced CT scan or MRI of the neck, chest, abdomen, pelvis is permissible, however; PET is preferred.

(7) Patients cannot have active central nervous system (CNS) disease. Patients that have been treated and asymptomatic are allowed on study.

(8) All participants must be screened for chronic hepatitis B virus (HBV) with hepatitis B viral load and serologies (core antibody, surface antigen, and surface antibody) within 30 days prior to enrollment.

Patients with positive Hep B core will need to be on HBV prophylaxis

Patients with positive Hep B core will need to be on HBV prophylaxis.

(9) Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. If actively on treatment, HCV viral load mut be undetectable 30 days prior to enrollment.

(10) Participants with known human immunodeficiency virus (HIV)-infection are eligible providing they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test (must be within 26 weeks prior to enrollment).

(11) Organ function as assessed by laboratory testing and Eastern Cooperate Oncology Group (ECOG) performance status 0-2 and or a Karnofsky performance score of equal or greater to 50 (see Section 20.1.1, Appendix A) for receipt of ruxolitinib and pembrolizumab.

Absolute Neutrophil Count ≥ 1000/μL (not growth factor independent)

Platelets ≥ 70,000/μL (or ≥50,000/mm3 if known bone marrow involvement with dose modifications allowed. See protocol for specific instructions for dose modifications).

Baseline hemoglobin level ≥ 8 g/dL (irrespective of bone marrow involvement).

Calculated creatinine clearance ≥ 30 ml/min using the Cockcroft-Gault formula

Bilirubin ≤ 2 x upper limit of normal (ULN)

Aspartate aminotransferase (AST) ≤ 2.5 × ULN

Alanine aminotransferase (ALT) ≤ 2.5 × ULN

(12) Ability to understand and the willingness to sign a written informed consent document.

(13) Patients with prior history of deep vein thrombosis (DVT) that has been treated or actively requiring anticoagulation are permitted to enroll.

(14) Due to the potential teratogenic effects, women of childbearing age must have a documented negative serum β-hCG measured within 2 weeks of starting treatment. Should a woman become pregnant or suspect she is pregnant while she is participating in this study, she should inform her treating physician and Incyte immediately (see protocol). Additionally, both women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence). Contraception should continue for 6 months after you stop taking study drug. Similarly, women must agree to not breastfeed during the entirety of the study period.

Exclusion Criteria

1\) Diagnosis of Adult T-Cell Leukemia/Lymphoma (ATLL)

2\) History of autoimmune disease that requires systemic treatment.

3\) Has a diagnosis of immunodeficiency or receiving immunosuppressive therapy within 7 days prior to the first dose of study drug.

4\) Actively chronic systemic steroids therapy (in dosing exceeding 10mg daily of prednisone or its drug equivalent). o Patients must be off steroid therapy exceeding 10mg or greater of prednisone (or its equivalent) at the start of therapy.

5\) Patients with HL and PMBCL patients must not be eligible and agreeable to autologous stem cell transplant. o Patients with PMBCL must not be eligible and agreeable to CAR-T.

6\) Allowed to have disease progression after or refractory to autologous bone marrow transplant.

7\) Progression after allogeneic stem cell transplantation (SCT) can be determined on a case-by-case basis after discussion with the primary investigator.

8\) History of solid organ transplant requiring active immunosuppression for which treatment with immunotherapy would be contraindicated.

9\) Active TB (Tuberculosis Bacillus) at time screening. Prior cases of adequately treated TB are permissible.

10\) Has severe hypersensitivity (≥ Grade 3) to pembrolizumab and/or any of its excipients.

11\) Has severe hypersensitivity (≥ Grade 3) to ruxolitinib and/or any of its excipients. Patients with G1 and G2 hypersensitivity remain eligible.

12\) Inability to swallow or take medications by mouth

13\) Is pregnant or breastfeeding or expected to conceive children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of trial treatment.

14\) History of concurrent and active malignancy for which he or she is currently receiving directed therapy for.

15\) History of major adverse cardiac events such as myocardial infraction or stroke within 6 months of enrollment. Cardiovascular events within 6 months such as pulmonary embolism and deep vein thrombosis is permissible if on therapeutic treatment.

16\) Subjects with active, systemic, and uncontrolled bacterial, viral, or fungal infections at the time of screening will be excluded from study participation. Exceptions include: Infections that have been appropriately treated, with evidence of clinical resolution and return to baseline organ function within 14 days prior to study entry.

Localized, non-systemic infections (e.g., uncomplicated urinary tract infections or cellulitis) that are being actively managed and are not associated with systemic symptoms.

Please see section protocol for eligibility requirements specifically for HCV, HBV, HIV and Tuberculosis infections at time of screening.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New York?

Yes, this clinical trial (NCT07283822) has an active research site in New York, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Non-Hodgkin Lymphoma Treatment Options in New York, NY

If you're searching for non-hodgkin lymphoma treatment options in New York, NY, this clinical trial (NCT07283822) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New York research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced non-hodgkin lymphoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all non-hodgkin lymphoma clinical trials near you to find additional studies recruiting in your area.

Non-Hodgkin Lymphoma Clinical Trial in New York, NY

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