Houston, TXNCT07086755Now EnrollingIRB Ready

Nonintubated Acute Respiratory Distress Syndrome (ARDS) Clinical Trial in Houston, TX

Access cutting-edge nonintubated acute respiratory distress syndrome (ards) treatment through this clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by Bentley J. Bobrow

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Expert Care in Houston

Access nonintubated acute respiratory distress syndrome (ards) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related nonintubated acute respiratory distress syndrome (ards) treatment provided free

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Check if you qualify for this nonintubated acute respiratory distress syndrome (ards) clinical trial in Houston, TX

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Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Nonintubated Acute Respiratory Distress Syndrome (ARDS) Study in Houston

The objective of this study is to assess the efficacy and safety of vadadustat for treating hospitalized patients with nonintubated Acute Respiratory Distress Syndrome (ARDS) secondary to pathogen-associated lung injury.

Sponsor: Bentley J. Bobrow

Who Can Participate

Inclusion Criteria

-Meets the definition of nonintubated ARDS per the 2024 Global Definition of ARDS that includes all the following (2A-2D):
2A. Risk factors and origin of pulmonary edema: Precipitated by an acute predisposing risk factor, specifically from a suspected pathogen-associated etiology such as pneumonia\
or non-pulmonary infection\*\
\[\*Pneumonia defined as known or suspected based on treating physician documentation or discussion, OR both of the following criteria: 1) Chest radiography with new infiltrates, consolidation, or cavitation and (2) Clinical signs of pneumonia (new cough, sputum, fever, or white blood cells (WBC) \> 12,000)\] \[\*\*Non-pulmonary infection defined as suspected or proven infection meeting any of the following criteria: treating clinician suspects a viral, bacterial, or fungal infection, or cultures ordered in the past 24h or positive cultures within 1 week; or orders for antimicrobial medication.\]
2B. Oxygenation: PaO2:FIO2 ≤ 300 mm Hg or SpO2:FIO2 ≤ 315 (if SpO2 ≤ 97%) on High-Flow Nasal Oxygen (HFNO) with flow of ≥ 30 L/min or non-invasive ventilation (NIV)/continuous positive airway pressure (CPAP) with at least 5 cm H2O end-expiratory pressure
2C. Timing: Acute onset or worsening of hypoxemic respiratory failure within 1 week of the estimated onset of the predisposing risk factor or new or worsening respiratory symptoms.
2D. Chest imaging: Chest infiltrates on radiography and computed tomography or B lines and/or consolidations on ultrasound not fully explained by effusions, atelectasis, or nodules/masses.

Exclusion Criteria

Hypersensitivity to vadadustat or any of its excipients
Placed on mechanical ventilation before randomization
Patients on home oxygen therapy
Time since hospital admission order placed \>72 hours
Hemoglobin above the gender-specific upper limit of normal (ULN) at randomization: 16 grams/deciliter (g/dL) for females and 18 g/dL for males
Patients with Aspartate transferase (AST) or Alanine aminotransferase (ALT) levels \>5 times the upper limit of normal
Patients with AST or ALT levels \>3 times the upper limit of normal along with a total bilirubin elevation of \>2 times the upper limit of normal.
Patients who have erythrocytosis or polycythemia vera
Patients with uncontrolled hypertension
Patients with active malignancy
Patients with liver cirrhosis or active, acute liver disease
Patients taking erythropoiesis-stimulating agents
Patient taking probenecid, rifampicin, gemfibrozil, or teriflunomide
Women who are pregnant or breastfeeding, or positive pregnancy test before randomization
Patients who are prisoners
Patients who are currently enrolled in any other interventional clinical trial
Patients who have any prior history of arterial or venous thromboembolism within the past 3 months
Patients with a history of myocardial infarction, cerebrovascular event, or acute coronary syndrome within the past 3 months
Patients with known or suspected tuberculosis infection
Moribund patient not expected to survive 48 hours

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT07086755) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Nonintubated Acute Respiratory Distress Syndrome (ARDS) Treatment Options in Houston, TX

If you're searching for nonintubated acute respiratory distress syndrome (ards) treatment options in Houston, TX, this clinical trial (NCT07086755) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced nonintubated acute respiratory distress syndrome (ards) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all nonintubated acute respiratory distress syndrome (ards) clinical trials near you to find additional studies recruiting in your area.

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