NCT06891534 · Mayo Clinic
Circadian Rhythms in Human Adipose
What this study is about
The goal of this study is to understand the underlying circadian rhythms in injected under the skin adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.
View original scientific description
The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.
Interventions
OTHER
Continuous Feeding
Participants will receive 24-hour continuous feeds through an NG tube
OTHER
Intermittent feeding
Participants will receive 3 boluses of feeding per day at regular meal times through an NG tube to mimic normal meals.
Primary outcome measures
rhythmicity of circadian clock mRNA in adipose tissue
Time frame: 24 hour
Genes from RNA-seq analysis will be defined as statistically rhythmic.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- BMI 20-25 kg/m2 or 30-37 kg/m2
- For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females.
- females: non pregnant or breastfeeding
- ability to provide written informed consent and follow study instructions
Exclusion criteria
- History of mediations that impact adipocyte/lipid metabolism
- sleep apnea
- sleep medication use
- employment in night or shift work
- extreme chronotypes
- Allergy to lidocaine
Where
- Rochester, Minnesota
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 14, 2026 · Source of record for eligibility and locations