NCT06790160 · Texas Tech University
Study of Patients Being Treated With Anti-obesity Medication
What this study is about
The goal of this observational study is to learn about the real-world effects of selected obesity medications in adults undergoing medical weight management. The main outcomes of interest are changes in body composition, routine clinical markers, muscular performance, and nutritional intake over the course of treatment.
View original scientific description
The goal of this observational study is to learn about the real-world effects of selected obesity medications in adults undergoing medical weight management. The main outcomes of interest are changes in body composition, routine clinical markers, muscular performance, and nutritional intake over the course of treatment. Additionally, the influence of lifestyle factors on changes in these outcome variables will be examined. Participants beginning treatment with selected obesity medications will undergo periodic body composition and muscular performance testing, as well as complete online surveys about their nutritional intake and physical activity and exercise participation. Additionally, routinely collected clinical information will be evaluated.
Primary outcome measures
Change in Total Lean Soft Tissue
Time frame: From baseline assessment to last available time point (follow-up assessments conducted ~6 months and ~17 months after baseline).
Change in total lean soft tissue assessed by dual-energy X-ray absorptiometry.
Change in Appendicular Lean Soft Tissue
Time frame: From baseline assessment to last available time point (follow-up assessments conducted ~6 months and ~17 months after baseline).
Change in appendicular lean soft tissue assessed by dual-energy X-ray absorptiometry.
Change in Total Fat Mass
Time frame: From baseline assessment to last available time point (follow-up assessments conducted ~6 months and ~17 months after baseline).
Change in total fat mass assessed by dual-energy X-ray absorptiometry.
Change in Handgrip Strength
Time frame: From baseline assessment to last available time point (follow-up assessments conducted ~3, ~6, and ~17 months after baseline).
Change in maximal handgrip strength as determined by a handgrip dynamometer.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Patient who is beginning treatment through Vineyard Virtual Health Clinic using semaglutide or tirzepatide. While the physician will individualize the treatment plans, the criteria for these medications will include, at a minimum: (A) a body mass index ≥30 kg/m2; OR (B) a BMI ≥27 kg/m2 plus at least one comorbidity.
- Patient who lives in drivable proximity to a city with an accepted DXA testing facility and is willing to report to the facility for periodic body composition testing.
Exclusion criteria
- Patients with type 2 diabetes.
- Patients who report not being willing or able to complete the assessments included in this research study.
- Patients who are currently pregnant or trying to become pregnant.
Where
- Lubbock, Texas
Collaborators
Vineyard Health Inc.
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 15, 2026 · Source of record for eligibility and locations