NCT07702461 · Ohio State University
Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists
What this study is about
This study examines how adults who take a GLP-1 receptor agonist medication (such as semaglutide \[Ozempic, Wegovy, Rybelsus\], liraglutide \[Saxenda, Victoza\], or tirzepatide \[Mounjaro, Zepbound\]) perform resistance (strength) training before and after starting their medication. GLP-1 medications are being prescribed more and more often to help people manage type 2 diabetes and lose weight.
View original scientific description
This study examines how adults who take a GLP-1 receptor agonist medication (such as semaglutide \[Ozempic, Wegovy, Rybelsus\], liraglutide \[Saxenda, Victoza\], or tirzepatide \[Mounjaro, Zepbound\]) perform resistance (strength) training before and after starting their medication. GLP-1 medications are being prescribed more and more often to help people manage type 2 diabetes and lose weight. These medications work well, but a known side effect is that people can lose lean (muscle) tissue along with fat. Losing muscle can make it harder to move, do everyday tasks, and stay strong as we age. Resistance training, things like lifting weights, using resistance bands, or doing push-ups and squats, is the most effective way to keep and build muscle. Yet most adults in the United States do not meet the recommended amount of resistance training, and very little is known about the resistance training habits of people who take GLP-1 medications. The purpose of this research is to systematically collect information from adults using GLP-1 medications so we can better understand: how often they do resistance training before and after starting the medication; what their sessions look like (frequency, duration, intensity, muscle groups); whether their resistance training is linked to how strong they feel and how well they can carry out daily activities; and what makes resistance training easier or harder while on a GLP-1 medication. Findings will help doctors, dietitians, exercise professionals, and researchers design better guidance and interventions to protect muscle mass, physical function, and quality of life in people using GLP-1 medications. Who can join: Adults 18 years or older who are currently taking a GLP-1 receptor agonist medication for type 2 diabetes, overweight or obesity, or weight management, and who have been on the medication for at least three months at a stable dose. Participants must be able to read and respond to the survey in English. People who are pregnant or planning bariatric surgery within the next three months are not eligible. What participants will do: The study is a single, anonymous, online survey. Interested individuals click the survey link, review a short consent page, and indicate their willingness to participate. Eligible participants then answer questions about their background, current health, GLP-1 medication and dose, resistance training habits before and after starting the medication, self-reported strength and function, and things that make resistance training easier or harder. There are no in-person visits, no exercise tests, and no blood draws. How long it takes: About 10 minutes total, in one online session. There is no follow-up after the survey and no compensation is offered. Data privacy: The survey is anonymous. No names, email addresses, or IP addresses are collected or linked to responses. The survey runs on Qualtrics, a secure, institution-approved platform hosted on Ohio State University servers. The research team hopes to enroll up to 200-300 adults across the United States.
Interventions
DRUG
Glucagon-Like Peptide-1 Agonist (GLP-1)
Adults currently taking a GLP-1 receptor agonist (GLP-1RA) medication for at least 3 months at a stable dose (e.g., semaglutide, liraglutide, tirzepatide, dulaglutide, or exenatide) complete a single, anonymous, online questionnaire administered via Qualtrics on Ohio State University secure servers. The survey (\~10 minutes) collects self-reported data on demographics, general health, current GLP-1RA medication with starting and current dose, height and weight, resistance training habits in a usual week before and since starting GLP-1RA therapy (assessed with the Muscle-Strengthening Exercise Questionnaire - Long Form; Shakespear-Druery et al., 2022), perceived muscular strength, activities of daily living, fatigue, quality of life, and barriers/facilitators to resistance training. No in-person visits, physical measurements, biospecimen collection, or follow-up contact are performed.
Primary outcome measures
Change in Resistance Training Status Before Versus Since GLP-1 Receptor Agonist Initiation
Time frame: Day 1
Resistance training (RT) status is assessed via the Muscle-Strengthening Exercise Questionnaire - Long Form (MSEQ-Long; Shakespear-Druery et al., 2022), which captures weekly frequency (days/week), session duration (minutes/session), intensity (OMNI-RES 0-10 scale), muscle groups targeted (7 major groups), and type of muscle-strengthening exercise across four modes (weight machines, bodyweight, resistance bands or free weights, holistic). Each participant reports RT during a usual week BEFORE starting their GLP-1 receptor agonist medication and during a usual week SINCE starting the medication. The primary outcome is the proportion of participants meeting ACSM muscle-strengthening guidelines (≥ 2 days per week engaging all major muscle groups) at each recall period, and the within-person change between the two recall periods.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Adult aged 18 years or older
- Currently taking a GLP-1 receptor agonist medication
- On the GLP-1 receptor agonist for at least 3 months
- Using the GLP-1 receptor agonist for type 2 diabetes, overweight or obesity, and/or weight management (self-reported)
- Stable GLP-1 receptor agonist dose for the past 4 to 8 weeks
- Able to read and respond to the survey in English
- Willing and able to provide informed consent electronically
Exclusion criteria
- Currently or planning to become pregnant
- Planned bariatric surgery within the next 3 months
- Recent bariatric surgery (within the past 3 months) or other conditions that substantially alter resistance training capacity (e.g., advanced cancer cachexia, severe mobility-limiting conditions)
- Unable to read or respond to the survey in English
Where
- Columbus, Ohio
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Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 24, 2026 · Source of record for eligibility and locations