St Louis, MONCT07853898Now EnrollingIRB Ready

Obesity / Overweight Clinical Trial in St Louis, MO

Access cutting-edge obesity / overweight treatment through this clinical trial at a research site in St Louis. Study-provided care at no cost to qualified participants.

Sponsored by St. Louis University

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Expert Care in St Louis

Access obesity / overweight specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related obesity / overweight treatment provided free

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Check if you qualify for this obesity / overweight clinical trial in St Louis, MO

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Why Participate?

  • No-Cost Study Care

  • Local to St Louis

    Convenient for MO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit St Louis site if eligible
  4. 4Begin participation

About This Obesity / Overweight Study in St Louis

This randomized controlled crossover study will examine the acute effects of pistachio consumption on postprandial metabolic responses in adults with overweight or obesity. Participants will complete two experimental conditions in randomized order. In one condition, participants will consume 30 g of pistachios with a standardized meal, and in the other condition they will receive an isocaloric refined-carbohydrate control condition with the standardized meal. The study will evaluate postprandial insulin and glucose responses over approximately 3 hours after meal consumption. Additional outcomes will include continuous glucose monitoring measures, blood lipid responses, appetite and satiety ratings, and exploratory measures related to insulin sensitivity and gastrointestinal hormone responses. The study is designed to determine whether pistachio consumption alters acute metabolic responses compared with an isocaloric refined-carbohydrate control in adults with overweight or obesity.

Sponsor: St. Louis University

Who Can Participate

Inclusion Criteria

Age 18-35 years, male or female, and able to provide informed consent.
BMI ≥25.0 kg/m². Waist circumference and BIA-derived body composition will also be assessed during screening and considered with BMI to help confirm that elevated BMI reflects excess adiposity rather than primarily high muscularity.
Weight stable, defined as no intentional weight loss or body weight change \>3 kg during the previous 3 months.
Generally healthy and not currently taking medications known to substantially affect glucose metabolism, insulin secretion, insulin sensitivity, appetite, or body weight. Stable thyroid hormone replacement for a well-controlled thyroid condition is not automatically

Exclusion Criteria

Able to complete a 10-12-hour overnight fast and refrain from vigorous exercise and alcohol for 24 hours before each test meal visit.
Able and willing to consume pistachios, the refined-carbohydrate control food, and the standardized breakfast meal. Exclusion Criteria:
Known diagnosis of type 1 or type 2 diabetes. Individuals with known prediabetes will not be excluded.
Clinically significant cardiovascular disease, including prior myocardial infarction or stroke, uncontrolled hypertension, clinically significant arrhythmia, or another cardiovascular condition that could make participation unsafe or meaningfully affect study outcomes.
Chronic kidney disease or another major medical condition that could make participation unsafe or meaningfully affect metabolic outcomes.
Current participation in a weight-loss program, use of weight-loss medications, or history of bariatric surgery within the past year.
Known allergy or intolerance to pistachios, tree nuts, peanuts/peanut butter, wheat/gluten, orange juice/citrus, or any other study-meal ingredient.
Celiac disease, Crohn's disease, ulcerative colitis, or another clinically significant gastrointestinal or malabsorption condition that could affect digestion, nutrient absorption, or metabolic responses.
Current ketogenic, very-low-carbohydrate, or medically prescribed diet that could meaningfully interfere with the standardized feeding protocol or metabolic outcomes.
Participation in another clinical research trial within the past 3 months that could affect participant safety or study outcomes.
Recent significant illness, infection, or surgery within the past 4 weeks that could affect participant safety or study outcomes.
Current or prior clinically significant eating disorder that, in the investigator's judgment, could make participation unsafe or interfere with the feeding protocol.
Current smoking, frequent nicotine use, or excessive alcohol use.
Pregnancy, planned pregnancy during the study period, or lactation.
Any condition or medication that, in the investigator's judgment, would make participation unsafe or interfere with outcome measures.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in St Louis?

Yes, this clinical trial (NCT07853898) has an active research site in St Louis, MO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Obesity / Overweight Treatment Options in St Louis, MO

If you're searching for obesity / overweight treatment options in St Louis, MO, this clinical trial (NCT07853898) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our St Louis research site is actively enrolling participants for this clinical trial. You'll receive care from experienced obesity / overweight specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all obesity / overweight clinical trials near you to find additional studies recruiting in your area.

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